Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically effective plasma concentrations of levodopa ranged from 3 to 12 nmol/ml. The duration, but not the magnitude, of clinical response was linearly related to plasma concentrations. The clinical response lagged behind the rise and fall of plasma levodopa. There was no evidence of idiosyncratic pharmacokinetic or pharmacodynamic responses to levodopa to explain the fluctuating response.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalNeurology
Volume36
Issue number6
DOIs
StatePublished - Jun 1986

ASJC Scopus subject areas

  • Clinical Neurology

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