Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically effective plasma concentrations of levodopa ranged from 3 to 12 nmol/ml. The duration, but not the magnitude, of clinical response was linearly related to plasma concentrations. The clinical response lagged behind the rise and fall of plasma levodopa. There was no evidence of idiosyncratic pharmacokinetic or pharmacodynamic responses to levodopa to explain the fluctuating response.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalNeurology
Volume36
Issue number6
StatePublished - 1986

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Levodopa
Pharmacokinetics
Carbidopa
Intravenous Infusions
Plasma
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients. / Nutt, John; Woodward, William.

In: Neurology, Vol. 36, No. 6, 1986, p. 739-744.

Research output: Contribution to journalArticle

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