Levels of Serum Ribonuclease as an Indicator of Renal Insufficiency in Patients with Leukemia

Timothy P. Karpetsky; Edward Neuwelt; Carl C. Levy

Levels of Serum Ribonuclease as an Indicator of Renal Insufficiency in Patients with Leukemia

Timothy P. Karpetsky, Edward Neuwelt, Carl C. Levy

Research output: Contribution to journal › Article › peer-review

Abstract

Serum ribonuclease (RNase) levels were measured in 29 patients with leukemia at various times during their illness and compared with 54 normal controls and 28 nonleukemic patients on chronic hemodialysis. Eighty-three % of the leukemic patients examined before therapy and with normal rates of glomerular filtration (as defined by creatinine clearance greater than 60 ml/min) had RNase levels that fell within the mean ± 2σ for the normal controls. Sixty-one % of the leukemic patients, studied at various times during the course of their illness, who had a creatinine clearance of >60 ml/min had RNase levels in the normal range. Ninety-three % of the leukemic patients studied with a creatinine clearance of

Original language	English (US)
Pages (from-to)	2015-2022
Number of pages	8
Journal	Cancer Research
Volume	37
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

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AU - Levy, Carl C.

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AB - Serum ribonuclease (RNase) levels were measured in 29 patients with leukemia at various times during their illness and compared with 54 normal controls and 28 nonleukemic patients on chronic hemodialysis. Eighty-three % of the leukemic patients examined before therapy and with normal rates of glomerular filtration (as defined by creatinine clearance greater than 60 ml/min) had RNase levels that fell within the mean ± 2σ for the normal controls. Sixty-one % of the leukemic patients, studied at various times during the course of their illness, who had a creatinine clearance of >60 ml/min had RNase levels in the normal range. Ninety-three % of the leukemic patients studied with a creatinine clearance of

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