Levels of Serum Ribonuclease as an Indicator of Renal Insufficiency in Patients with Leukemia

Timothy P. Karpetsky, Edward Neuwelt, Carl C. Levy

Research output: Contribution to journalArticle

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Abstract

Serum ribonuclease (RNase) levels were measured in 29 patients with leukemia at various times during their illness and compared with 54 normal controls and 28 nonleukemic patients on chronic hemodialysis. Eighty-three % of the leukemic patients examined before therapy and with normal rates of glomerular filtration (as defined by creatinine clearance greater than 60 ml/min) had RNase levels that fell within the mean ± 2σ for the normal controls. Sixty-one % of the leukemic patients, studied at various times during the course of their illness, who had a creatinine clearance of >60 ml/min had RNase levels in the normal range. Ninety-three % of the leukemic patients studied with a creatinine clearance of

Original languageEnglish (US)
Pages (from-to)2015-2022
Number of pages8
JournalCancer Research
Volume37
Publication statusPublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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