Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: A case report and review of the literature

Mazdak A. Khalighi, Andrew Yue, Mei Tsuey Hwang, William D. Wallace

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)618-621
Number of pages4
JournalClinical Kidney Journal
Volume6
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Amyloid
  • Lect2
  • Pulmonary-renal syndrome

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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