Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome

A case report and review of the literature

Mazdak Khalighi, Andrew Yue, Mei Tsuey Hwang, William D. Wallace

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)618-621
Number of pages4
JournalClinical Kidney Journal
Volume6
Issue number6
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Chemotactic Factors
Amyloidosis
Leukocytes
Kidney
Lung
Kidney Diseases
Differential Diagnosis
Biopsy
Rapidly progressive glomerulonephritis with pulmonary hemorrhage

Keywords

  • Amyloid
  • Lect2
  • Pulmonary-renal syndrome

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome : A case report and review of the literature. / Khalighi, Mazdak; Yue, Andrew; Hwang, Mei Tsuey; Wallace, William D.

In: Clinical Kidney Journal, Vol. 6, No. 6, 01.12.2013, p. 618-621.

Research output: Contribution to journalReview article

@article{0791feaedda9420fafa73aa1ef59677a,
title = "Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: A case report and review of the literature",
abstract = "Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.",
keywords = "Amyloid, Lect2, Pulmonary-renal syndrome",
author = "Mazdak Khalighi and Andrew Yue and Hwang, {Mei Tsuey} and Wallace, {William D.}",
year = "2013",
month = "12",
day = "1",
doi = "10.1093/ckj/sft126",
language = "English (US)",
volume = "6",
pages = "618--621",
journal = "CKJ: Clinical Kidney Journal",
issn = "2048-8505",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome

T2 - A case report and review of the literature

AU - Khalighi, Mazdak

AU - Yue, Andrew

AU - Hwang, Mei Tsuey

AU - Wallace, William D.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.

AB - Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.

KW - Amyloid

KW - Lect2

KW - Pulmonary-renal syndrome

UR - http://www.scopus.com/inward/record.url?scp=84890340495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890340495&partnerID=8YFLogxK

U2 - 10.1093/ckj/sft126

DO - 10.1093/ckj/sft126

M3 - Review article

VL - 6

SP - 618

EP - 621

JO - CKJ: Clinical Kidney Journal

JF - CKJ: Clinical Kidney Journal

SN - 2048-8505

IS - 6

ER -