Leukocyte adherence in atopic dermatitis

Diminished responses to histamine and isoproterenol

H. Thulin, Jon Hanifin, R. Bryant

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Leukocyte adherence was examined in atopic and normal subjects and the influence of histamine and the beta-adrenergic agonist, isoproterenol, evaluated. Atopics included patients with mild to severe atopic dermatitis and patients with asthma and hayfever. No intergroup differences in leukocyte adherence of untreated leukocytes could be demonstrated, but there was a significantly smaller histamine and isoproterenol effect on the adherence of cells from patients with atopic dermatitis and hayfever. The induced inhibition of leukocyte adherence by histamine could be blocked by the H-2 histamine receptor antagonist, metiamide, suggesting that this effect may be mediated via cAMP. These findings support the hypothesis that atopic dermatitis patients may have a defect or blockade of their cellular response to histamine.

Original languageEnglish (US)
Pages (from-to)235-258
Number of pages24
JournalActa Dermato-Venereologica
Volume60
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Atopic Dermatitis
Isoproterenol
Histamine
Leukocytes
Seasonal Allergic Rhinitis
Metiamide
Histamine Agents
Histamine Receptors
Adrenergic beta-Agonists
Histamine Antagonists
Patient Compliance

ASJC Scopus subject areas

  • Dermatology

Cite this

Leukocyte adherence in atopic dermatitis : Diminished responses to histamine and isoproterenol. / Thulin, H.; Hanifin, Jon; Bryant, R.

In: Acta Dermato-Venereologica, Vol. 60, No. 3, 1980, p. 235-258.

Research output: Contribution to journalArticle

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