Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance

Su M. Metcalfe; Poorni A.De S. Muthukumarana; H. Lorraine Thompson; Melissa A. Haendel; Gary E. Lyons

doi:10.1016/j.febslet.2004.12.027

Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance

Su M. Metcalfe, Poorni A.De S. Muthukumarana, H. Lorraine Thompson, Melissa A. Haendel, Gary E. Lyons

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot ^+/+, axot^+/- and axot^-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.

Original language	English (US)
Pages (from-to)	609-614
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	3
DOIs	https://doi.org/10.1016/j.febslet.2004.12.027
State	Published - Jan 31 2005
Externally published	Yes

Keywords

Axotrophin
Immune regulation
Leukaemia inhibitory factor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2004.12.027

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title = "Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance",

abstract = "Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot +/+, axot+/- and axot-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.",

keywords = "Axotrophin, Immune regulation, Leukaemia inhibitory factor",

author = "Metcalfe, {Su M.} and Muthukumarana, {Poorni A.De S.} and Thompson, {H. Lorraine} and Haendel, {Melissa A.} and Lyons, {Gary E.}",

note = "Funding Information: We are grateful to Professor R.B. Heap for critical review of the manuscript and to Dr. S. Thiru for histological assessments. This work was supported by The Dunhill Medical Research Trust (S.M.M.), The Henry Smith Charity (S.M.M.), NIH: HD29471 (G.E.L.); GM077507-18 and MH11560 (M.A.H.). G.E.L is an Established Investigator of the American Heart Association. ",

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doi = "10.1016/j.febslet.2004.12.027",

language = "English (US)",

volume = "579",

pages = "609--614",

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AU - Metcalfe, Su M.

AU - Muthukumarana, Poorni A.De S.

AU - Thompson, H. Lorraine

AU - Haendel, Melissa A.

AU - Lyons, Gary E.

N1 - Funding Information: We are grateful to Professor R.B. Heap for critical review of the manuscript and to Dr. S. Thiru for histological assessments. This work was supported by The Dunhill Medical Research Trust (S.M.M.), The Henry Smith Charity (S.M.M.), NIH: HD29471 (G.E.L.); GM077507-18 and MH11560 (M.A.H.). G.E.L is an Established Investigator of the American Heart Association.

PY - 2005/1/31

Y1 - 2005/1/31

N2 - Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot +/+, axot+/- and axot-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.

AB - Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot +/+, axot+/- and axot-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.

KW - Axotrophin

KW - Immune regulation

KW - Leukaemia inhibitory factor

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Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance

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Keywords

ASJC Scopus subject areas

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