Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance

Su M. Metcalfe, Poorni A.De S. Muthukumarana, H. Lorraine Thompson, Melissa A. Haendel, Gary E. Lyons

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot +/+, axot+/- and axot-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.

Original languageEnglish (US)
Pages (from-to)609-614
Number of pages6
JournalFEBS Letters
Volume579
Issue number3
DOIs
StatePublished - Jan 31 2005

Keywords

  • Axotrophin
  • Immune regulation
  • Leukaemia inhibitory factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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