Leu-3+ lymphocytes account for increased CSF cellularity

Arthur A. Vandenbark, Jan De Saedeleer, Harie Heyligen, Rene Dom, Jef Raus, Jan Stragier, Herwig Carton

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Inflammatory conditions of the central nervous system (CNS) are often marked by an increase in lymphocyte number in the cerebrospinal fluid (CSF). In order to determine if changes in CSF cell numbers can alter T-lymphocyte subset composition in CSF or in blood, cell surface markers were evaluated in 25 CSF and paired blood samples from a variety of neurologically affected patients. T-cell subset levels in peripheral blood did not reflect subset levels in paired CSF samples. However, CSF samples with elevated cell numbers (> 3 cells/mm3) had significantly increased levels of Leu-3+ T-cells (P < 0.001), but not Leu-2+ T-cells relative to CSF samples with low cell counts. These data suggest a selective increase in the Leu-3+ T-lymphocyte subset in CSFs with increased cellularity in patients with acute neurologic signs.

Original languageEnglish (US)
Pages (from-to)103-114
Number of pages12
JournalJournal of Neuroimmunology
Volume8
Issue numberC
DOIs
StatePublished - 1985

Keywords

  • Central nervous system
  • Cerebrospinal fluid
  • Leu-2 and Leu-3 T-cells
  • Lymphocytes
  • T-cell subsets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Vandenbark, A. A., Saedeleer, J. D., Heyligen, H., Dom, R., Raus, J., Stragier, J., & Carton, H. (1985). Leu-3+ lymphocytes account for increased CSF cellularity. Journal of Neuroimmunology, 8(C), 103-114. https://doi.org/10.1016/S0165-5728(85)80051-5