Lessons learned from next-generation sequencing in head and neck cancer

Myriam Loyo, Ryan J. Li, Chetan Bettegowda, Curtis R. Pickering, Mitchell J. Frederick, Jeffrey N. Myers, Nishant Agrawal

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalHead and Neck
Volume35
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • head and neck squamous cell carcinoma
  • mutations
  • next generation sequencing
  • oncogene
  • tumor suppressor gene

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Lessons learned from next-generation sequencing in head and neck cancer'. Together they form a unique fingerprint.

Cite this