TY - JOUR
T1 - Lessons in nonhuman primate models for AIDS vaccine research
T2 - From minefields to milestones
AU - Lifson, Jeffrey D.
AU - Haigwood, Nancy L.
PY - 2012/6
Y1 - 2012/6
N2 - Nonhuman primate (NHP) disease models for AIDS have made important contributions to the search for effective vaccines for AIDS. Viral diversity, persistence, capacity for immune evasion, and safety considerations have limited development of conventional approaches using killed or attenuated vaccines, necessitating the development of novel approaches. Here we highlight the knowledge gained and lessons learned in testing vaccine concepts in different virus/NHP host combinations.
AB - Nonhuman primate (NHP) disease models for AIDS have made important contributions to the search for effective vaccines for AIDS. Viral diversity, persistence, capacity for immune evasion, and safety considerations have limited development of conventional approaches using killed or attenuated vaccines, necessitating the development of novel approaches. Here we highlight the knowledge gained and lessons learned in testing vaccine concepts in different virus/NHP host combinations.
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U2 - 10.1101/cshperspect.a007310
DO - 10.1101/cshperspect.a007310
M3 - Article
C2 - 22675663
AN - SCOPUS:84865093951
SN - 2157-1422
VL - 2
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 6
M1 - a007310
ER -