Lessons in nonhuman primate models for AIDS vaccine research: From minefields to milestones

Jeffrey D. Lifson, Nancy L. Haigwood

    Research output: Contribution to journalArticle

    38 Scopus citations

    Abstract

    Nonhuman primate (NHP) disease models for AIDS have made important contributions to the search for effective vaccines for AIDS. Viral diversity, persistence, capacity for immune evasion, and safety considerations have limited development of conventional approaches using killed or attenuated vaccines, necessitating the development of novel approaches. Here we highlight the knowledge gained and lessons learned in testing vaccine concepts in different virus/NHP host combinations.

    Original languageEnglish (US)
    Article numbera007310
    JournalCold Spring Harbor Perspectives in Medicine
    Volume2
    Issue number6
    DOIs
    StatePublished - Jun 2012

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    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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