Lesions of rostral ventrolateral medulla (RVLM) or A5 reduce the 2-deoxy-glucose (2-DG)-evoked elevations in plasma epinephrine and blood glucose

Shaun Morrison, A. Houle

Research output: Contribution to journalArticle

Abstract

Tu correct the glucopnea elicited by intravenous 2-DG, reflex mechanisms within the brainstem produre an increase in plasma epinephrine and a rise in blood glucose. To determine if neurons in the vasomotor region of the RVLM or in the region of the A5, noradrenergic cell group participate in the 2-DG-evoked increase in sympathetic outflow to the adrenal medulla, we compared the magnitudes of the increases in femoral arterial plasma epinephrine and blood glucose following 2-DG administration (300 mg/kg) in control rats (anesthetized with urethane/chloralose, paralyzed, ventilated with 100% O2) with those in rats receiving bilateral electrolytic lesions in the RVLM or the A5 region. Lesions of the RVLM which lowered arterial pressure also reduced the 2-DG-evoked rise in plasma epinephrine and glucose. Lesions of the A5 produced an increase in basal plasma epinephrine and glucose. Subsequent 2-DG administration did not further increase plasma epinephrine and produced a reduced increase in blood glucose. We conclude that neurons (or axons) in the RVLM and the A5 regions are involved in regulating the increased sympathetic outflow to the adrenal medulla that comprises an important part of the autonomic response to hypoglycemia.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

2-deoxyglucose
epinephrine
lesions (animal)
blood glucose
Epinephrine
Blood Glucose
Plasmas
Glucose
adrenal medulla
Adrenal Medulla
neurons
chloralose
urethane
Neurons
glucose
hypoglycemia
rats
brain stem
Rat control
thighs

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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title = "Lesions of rostral ventrolateral medulla (RVLM) or A5 reduce the 2-deoxy-glucose (2-DG)-evoked elevations in plasma epinephrine and blood glucose",
abstract = "Tu correct the glucopnea elicited by intravenous 2-DG, reflex mechanisms within the brainstem produre an increase in plasma epinephrine and a rise in blood glucose. To determine if neurons in the vasomotor region of the RVLM or in the region of the A5, noradrenergic cell group participate in the 2-DG-evoked increase in sympathetic outflow to the adrenal medulla, we compared the magnitudes of the increases in femoral arterial plasma epinephrine and blood glucose following 2-DG administration (300 mg/kg) in control rats (anesthetized with urethane/chloralose, paralyzed, ventilated with 100{\%} O2) with those in rats receiving bilateral electrolytic lesions in the RVLM or the A5 region. Lesions of the RVLM which lowered arterial pressure also reduced the 2-DG-evoked rise in plasma epinephrine and glucose. Lesions of the A5 produced an increase in basal plasma epinephrine and glucose. Subsequent 2-DG administration did not further increase plasma epinephrine and produced a reduced increase in blood glucose. We conclude that neurons (or axons) in the RVLM and the A5 regions are involved in regulating the increased sympathetic outflow to the adrenal medulla that comprises an important part of the autonomic response to hypoglycemia.",
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AU - Morrison, Shaun

AU - Houle, A.

PY - 1997

Y1 - 1997

N2 - Tu correct the glucopnea elicited by intravenous 2-DG, reflex mechanisms within the brainstem produre an increase in plasma epinephrine and a rise in blood glucose. To determine if neurons in the vasomotor region of the RVLM or in the region of the A5, noradrenergic cell group participate in the 2-DG-evoked increase in sympathetic outflow to the adrenal medulla, we compared the magnitudes of the increases in femoral arterial plasma epinephrine and blood glucose following 2-DG administration (300 mg/kg) in control rats (anesthetized with urethane/chloralose, paralyzed, ventilated with 100% O2) with those in rats receiving bilateral electrolytic lesions in the RVLM or the A5 region. Lesions of the RVLM which lowered arterial pressure also reduced the 2-DG-evoked rise in plasma epinephrine and glucose. Lesions of the A5 produced an increase in basal plasma epinephrine and glucose. Subsequent 2-DG administration did not further increase plasma epinephrine and produced a reduced increase in blood glucose. We conclude that neurons (or axons) in the RVLM and the A5 regions are involved in regulating the increased sympathetic outflow to the adrenal medulla that comprises an important part of the autonomic response to hypoglycemia.

AB - Tu correct the glucopnea elicited by intravenous 2-DG, reflex mechanisms within the brainstem produre an increase in plasma epinephrine and a rise in blood glucose. To determine if neurons in the vasomotor region of the RVLM or in the region of the A5, noradrenergic cell group participate in the 2-DG-evoked increase in sympathetic outflow to the adrenal medulla, we compared the magnitudes of the increases in femoral arterial plasma epinephrine and blood glucose following 2-DG administration (300 mg/kg) in control rats (anesthetized with urethane/chloralose, paralyzed, ventilated with 100% O2) with those in rats receiving bilateral electrolytic lesions in the RVLM or the A5 region. Lesions of the RVLM which lowered arterial pressure also reduced the 2-DG-evoked rise in plasma epinephrine and glucose. Lesions of the A5 produced an increase in basal plasma epinephrine and glucose. Subsequent 2-DG administration did not further increase plasma epinephrine and produced a reduced increase in blood glucose. We conclude that neurons (or axons) in the RVLM and the A5 regions are involved in regulating the increased sympathetic outflow to the adrenal medulla that comprises an important part of the autonomic response to hypoglycemia.

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