Leptin stimulates sympathetic axon outgrowth

Michael J. Pellegrino, Belinda McCully, Beth Habecker

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The neurohormone leptin regulates energy homeostasis. Circulating levels of leptin secreted by adipose tissue act on hypothalamic neurons in the brain leading to decreased appetite and increased energy expenditure. Although leptin signaling in the central nervous system (CNS) is fundamental to its ability to regulate the body's metabolic balance, leptin also has a variety of effects in many peripheral tissues including the heart, the liver, and the sympathetic nervous system. Leptin stimulation of the hypothalamus can stimulate glucose uptake via the sympathetic nervous system in heart, muscle, and brown adipose tissue. Leptin receptors (Ob-Rb) are also expressed by peripheral sympathetic neurons, but their functional role is not clear. In this study, we found that leptin stimulates axonal growth of both adult and neonatal sympathetic neurons in vitro. Leptin stimulates acute activation of the transcription factor STAT3 via phosphorylation of tyrosine 705. STAT3 phosphorylation is required for leptin-stimulated sympathetic axon outgrowth. Thus, circulating levels of leptin may enhance sympathetic nerve innervation of peripheral tissues.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalNeuroscience Letters
Volume566
DOIs
StatePublished - Apr 30 2014

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Leptin
Sympathetic Nervous System
Neurons
Phosphorylation
Neuronal Outgrowth
Leptin Receptors
STAT3 Transcription Factor
Aptitude
Brown Adipose Tissue
Appetite
Peripheral Nerves
Energy Metabolism
Hypothalamus
Neurotransmitter Agents
Tyrosine
Adipose Tissue
Myocardium
Homeostasis
Central Nervous System
Glucose

Keywords

  • Axon outgrowth
  • Cardiac arrhythmia
  • Leptin
  • Obesity
  • STAT3

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Leptin stimulates sympathetic axon outgrowth. / Pellegrino, Michael J.; McCully, Belinda; Habecker, Beth.

In: Neuroscience Letters, Vol. 566, 30.04.2014, p. 1-5.

Research output: Contribution to journalArticle

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