Leptin mediates the increase in blood pressure associated with obesity

Stephanie E. Simonds, Jack T. Pryor, Eric Ravussin, Frank L. Greenway, Ralph Dileone, Andrew M. Allen, Jaspreet Bassi, Joel K. Elmquist, Julia M. Keogh, Elana Henning, Martin G. Myers, Julio Licinio, Russell D. Brown, Pablo J. Enriori, Stephen O'Rahilly, Scott M. Sternson, Kevin Grove, David C. Spanswick, I. Sadaf Farooqi, Michael A. Cowley

    Research output: Contribution to journalArticle

    144 Citations (Scopus)

    Abstract

    Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species.

    Original languageEnglish (US)
    Pages (from-to)1404-1416
    Number of pages13
    JournalCell
    Volume159
    Issue number6
    DOIs
    StatePublished - Dec 4 2014

    Fingerprint

    Blood pressure
    Leptin
    Obesity
    Leptin Receptors
    Blood Pressure
    Hypothalamus
    Nutrition
    Diet
    Weights and Measures
    Morbid Obesity
    Hypotension
    Rodentia
    Cardiovascular Diseases
    Neurons
    Animals
    Mutation
    Antibodies
    Networks (circuits)

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Simonds, S. E., Pryor, J. T., Ravussin, E., Greenway, F. L., Dileone, R., Allen, A. M., ... Cowley, M. A. (2014). Leptin mediates the increase in blood pressure associated with obesity. Cell, 159(6), 1404-1416. https://doi.org/10.1016/j.cell.2014.10.058

    Leptin mediates the increase in blood pressure associated with obesity. / Simonds, Stephanie E.; Pryor, Jack T.; Ravussin, Eric; Greenway, Frank L.; Dileone, Ralph; Allen, Andrew M.; Bassi, Jaspreet; Elmquist, Joel K.; Keogh, Julia M.; Henning, Elana; Myers, Martin G.; Licinio, Julio; Brown, Russell D.; Enriori, Pablo J.; O'Rahilly, Stephen; Sternson, Scott M.; Grove, Kevin; Spanswick, David C.; Farooqi, I. Sadaf; Cowley, Michael A.

    In: Cell, Vol. 159, No. 6, 04.12.2014, p. 1404-1416.

    Research output: Contribution to journalArticle

    Simonds, SE, Pryor, JT, Ravussin, E, Greenway, FL, Dileone, R, Allen, AM, Bassi, J, Elmquist, JK, Keogh, JM, Henning, E, Myers, MG, Licinio, J, Brown, RD, Enriori, PJ, O'Rahilly, S, Sternson, SM, Grove, K, Spanswick, DC, Farooqi, IS & Cowley, MA 2014, 'Leptin mediates the increase in blood pressure associated with obesity', Cell, vol. 159, no. 6, pp. 1404-1416. https://doi.org/10.1016/j.cell.2014.10.058
    Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM et al. Leptin mediates the increase in blood pressure associated with obesity. Cell. 2014 Dec 4;159(6):1404-1416. https://doi.org/10.1016/j.cell.2014.10.058
    Simonds, Stephanie E. ; Pryor, Jack T. ; Ravussin, Eric ; Greenway, Frank L. ; Dileone, Ralph ; Allen, Andrew M. ; Bassi, Jaspreet ; Elmquist, Joel K. ; Keogh, Julia M. ; Henning, Elana ; Myers, Martin G. ; Licinio, Julio ; Brown, Russell D. ; Enriori, Pablo J. ; O'Rahilly, Stephen ; Sternson, Scott M. ; Grove, Kevin ; Spanswick, David C. ; Farooqi, I. Sadaf ; Cowley, Michael A. / Leptin mediates the increase in blood pressure associated with obesity. In: Cell. 2014 ; Vol. 159, No. 6. pp. 1404-1416.
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    AU - O'Rahilly, Stephen

    AU - Sternson, Scott M.

    AU - Grove, Kevin

    AU - Spanswick, David C.

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