Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate

Baoxin Li, Zhigang Shi, Priscila A. Cassaglia, Virginia Brooks

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although leptin is known to increase sympathetic nerve activity (SNA), we tested the hypothesis that leptin also enhances baroreflex control of SNA and heart rate (HR). Using α-chloralose anesthetized male rats, mean arterial pressure (MAP), HR, lumbar SNA (LSNA), splanchnic SNA (SSNA), and renal SNA (RSNA) were recorded before and for 2 hours after lateral cerebroventricular leptin or artificial cerebrospinal fluid administration. Baroreflex function was assessed using a 4-parameter sigmoidal fit of HR and SNA responses to slow ramp (3-5 minutes) changes in MAP, induced by intravenous infusion of nitroprusside and phenylephrine. Leptin (3 μg) increased (P

Original languageEnglish (US)
Pages (from-to)812-819
Number of pages8
JournalHypertension
Volume61
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Splanchnic Nerves
Baroreflex
Prosencephalon
Leptin
Heart Rate
Kidney
Arterial Pressure
Chloralose
Architectural Accessibility
Viscera
Nitroprusside
Phenylephrine
Intravenous Infusions
Cerebrospinal Fluid

Keywords

  • lumbar sympathetic nerve activity
  • male rats
  • methscopolamine
  • parasympathetic
  • renal sympathetic nerve activity
  • splanchnic sympathetic nerve activity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate. / Li, Baoxin; Shi, Zhigang; Cassaglia, Priscila A.; Brooks, Virginia.

In: Hypertension, Vol. 61, No. 4, 04.2013, p. 812-819.

Research output: Contribution to journalArticle

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