Lens cytoskeleton and transparency: A model

John I. Clark, H. Matsushima, L. L. David, J. M. Clark

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.1 Since that time, tubulin, actin, vimentin and intermediate filaments have been identified and found to function in mitosis, motility and cellular morphology during lens cell differentiation.2-10 A role for the cytoskeleton in accommodation has been proposed3,8,9 and modification of the cytoskeletal proteins has been observed in several cataract models.4,11-21 Recently, a progressive increase in protein aggregation and lens opacification was found to correspond with the loss of cytoskeletal protein in the selenite model for cataract.22 In the present report a model is proposed for the role of tubulin, actin, vimentin, spectrin and the lens-specific filaments, filensin and CP49, in the establishment and maintenance of transparent lens cell structure.

Original languageEnglish (US)
Pages (from-to)417-424
Number of pages8
JournalEye (Basingstoke)
Volume13
Issue number3
DOIs
StatePublished - May 1999

Keywords

  • Cataract
  • Cytoskeleton
  • Lens
  • Opacity
  • Transparency

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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