Lemierre syndrome: A complication of acute pharyngitis

Andrea Williams, Mark Nagy, Jennifer Wingate, Luna Bailey, Mark Wax

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Lemierre syndrome, otherwise known as postanginal sepsis or necrobacillosis, is an illness that originates as an acute pharyngitis or tonsillitis which progresses to sepsis, usually fusobacterial, due to suppurative thrombophlebitis of the internal jugular vein. Septic thromboemboli then seed various organs, resulting in multiple organ system pathology, most commonly affecting pulmonary and hepatic systems and joints. Although rare in the age of antibiotics, this disease typically affects previously healthy adolescents with varied clinical manifestations depending upon organ system involvement (A. Lemierre, Lancet March (1936) 701-703; J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). Prompt diagnosis based on clinical presentation, radiologic findings, particularly CT scanning with contrast and a high index of suspicion, is necessary in order to institute often life saving therapy (J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). We will present two cases of Lemierre syndrome, review it's clinical presentation, anatomic considerations, particularly it's relationship to the parapharyngeal space, radiographic findings, potential life threatening complications and finally, a unique approach to therapy.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume45
Issue number1
DOIs
StatePublished - Sep 15 1998
Externally publishedYes

Fingerprint

Lemierre Syndrome
Pharyngitis
Fusobacterium Infections
Tonsillitis
Thrombophlebitis
Jugular Veins
Seeds
Sepsis
Joints
Pathology
Anti-Bacterial Agents
Lung
Liver
Therapeutics

Keywords

  • Acute pharyngitis
  • Lemierre syndrome
  • Multiple organ system pathology

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Lemierre syndrome : A complication of acute pharyngitis. / Williams, Andrea; Nagy, Mark; Wingate, Jennifer; Bailey, Luna; Wax, Mark.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 45, No. 1, 15.09.1998, p. 51-57.

Research output: Contribution to journalArticle

Williams, Andrea ; Nagy, Mark ; Wingate, Jennifer ; Bailey, Luna ; Wax, Mark. / Lemierre syndrome : A complication of acute pharyngitis. In: International Journal of Pediatric Otorhinolaryngology. 1998 ; Vol. 45, No. 1. pp. 51-57.
@article{129df0c3f6ac4bbebb1e3e5b7de2f5d2,
title = "Lemierre syndrome: A complication of acute pharyngitis",
abstract = "Lemierre syndrome, otherwise known as postanginal sepsis or necrobacillosis, is an illness that originates as an acute pharyngitis or tonsillitis which progresses to sepsis, usually fusobacterial, due to suppurative thrombophlebitis of the internal jugular vein. Septic thromboemboli then seed various organs, resulting in multiple organ system pathology, most commonly affecting pulmonary and hepatic systems and joints. Although rare in the age of antibiotics, this disease typically affects previously healthy adolescents with varied clinical manifestations depending upon organ system involvement (A. Lemierre, Lancet March (1936) 701-703; J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). Prompt diagnosis based on clinical presentation, radiologic findings, particularly CT scanning with contrast and a high index of suspicion, is necessary in order to institute often life saving therapy (J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). We will present two cases of Lemierre syndrome, review it's clinical presentation, anatomic considerations, particularly it's relationship to the parapharyngeal space, radiographic findings, potential life threatening complications and finally, a unique approach to therapy.",
keywords = "Acute pharyngitis, Lemierre syndrome, Multiple organ system pathology",
author = "Andrea Williams and Mark Nagy and Jennifer Wingate and Luna Bailey and Mark Wax",
year = "1998",
month = "9",
day = "15",
doi = "10.1016/S0165-5876(98)00092-5",
language = "English (US)",
volume = "45",
pages = "51--57",
journal = "International Journal of Pediatric Otorhinolaryngology",
issn = "0165-5876",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Lemierre syndrome

T2 - A complication of acute pharyngitis

AU - Williams, Andrea

AU - Nagy, Mark

AU - Wingate, Jennifer

AU - Bailey, Luna

AU - Wax, Mark

PY - 1998/9/15

Y1 - 1998/9/15

N2 - Lemierre syndrome, otherwise known as postanginal sepsis or necrobacillosis, is an illness that originates as an acute pharyngitis or tonsillitis which progresses to sepsis, usually fusobacterial, due to suppurative thrombophlebitis of the internal jugular vein. Septic thromboemboli then seed various organs, resulting in multiple organ system pathology, most commonly affecting pulmonary and hepatic systems and joints. Although rare in the age of antibiotics, this disease typically affects previously healthy adolescents with varied clinical manifestations depending upon organ system involvement (A. Lemierre, Lancet March (1936) 701-703; J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). Prompt diagnosis based on clinical presentation, radiologic findings, particularly CT scanning with contrast and a high index of suspicion, is necessary in order to institute often life saving therapy (J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). We will present two cases of Lemierre syndrome, review it's clinical presentation, anatomic considerations, particularly it's relationship to the parapharyngeal space, radiographic findings, potential life threatening complications and finally, a unique approach to therapy.

AB - Lemierre syndrome, otherwise known as postanginal sepsis or necrobacillosis, is an illness that originates as an acute pharyngitis or tonsillitis which progresses to sepsis, usually fusobacterial, due to suppurative thrombophlebitis of the internal jugular vein. Septic thromboemboli then seed various organs, resulting in multiple organ system pathology, most commonly affecting pulmonary and hepatic systems and joints. Although rare in the age of antibiotics, this disease typically affects previously healthy adolescents with varied clinical manifestations depending upon organ system involvement (A. Lemierre, Lancet March (1936) 701-703; J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). Prompt diagnosis based on clinical presentation, radiologic findings, particularly CT scanning with contrast and a high index of suspicion, is necessary in order to institute often life saving therapy (J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). We will present two cases of Lemierre syndrome, review it's clinical presentation, anatomic considerations, particularly it's relationship to the parapharyngeal space, radiographic findings, potential life threatening complications and finally, a unique approach to therapy.

KW - Acute pharyngitis

KW - Lemierre syndrome

KW - Multiple organ system pathology

UR - http://www.scopus.com/inward/record.url?scp=0032530835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032530835&partnerID=8YFLogxK

U2 - 10.1016/S0165-5876(98)00092-5

DO - 10.1016/S0165-5876(98)00092-5

M3 - Article

C2 - 9804020

AN - SCOPUS:0032530835

VL - 45

SP - 51

EP - 57

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

SN - 0165-5876

IS - 1

ER -