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Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages
Jan M. Boitz, Buddy Ullman
Biochemistry & Molecular Biology
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peer-review
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Agriculture & Biology
adenine phosphoribosyltransferase
83%
amastigotes
68%
Leishmania donovani
68%
xanthine
64%
hypoxanthine
62%
guanine
58%
purines
54%
macrophages
47%
promastigotes
43%
adenine deaminase
31%
viability
26%
enzymes
23%
Leishmania
20%
bone marrow
18%
pathogenicity
14%
developmental stages
12%
parasites
11%
nutrients
10%
mutants
10%
mice
10%
infection
9%
testing
6%
genes
6%
Medicine & Life Sciences
xanthine phosphoribosyltransferase
100%
Adenine Phosphoribosyltransferase
87%
Hypoxanthine Phosphoribosyltransferase
72%
Leishmania donovani
71%
purine
60%
Macrophages
36%
adenine deaminase
33%
Enzymes
28%
In Vitro Techniques
22%
Leishmania
20%
Life Cycle Stages
18%
Nutrients
14%
Parasites
14%
Infections
8%
Genes
7%