Left ventricular size, output, and structure during guinea pig pregnancy.

M. Morton, H. Tsang, Alan (Roger) Hohimer, D. Ross, Kent Thornburg, J. Faber, J. Metcalfe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We investigated left ventricular (LV) hemodynamics, pressure-volume relations, and morphometry to determine what cardiac changes characterize pregnancy in the guinea pig. Time-bred virgin guinea pigs were paired by weight with unbred controls. Hemodynamic studies and LV pressure-volume relations were obtained on days 59-68 of the 68-day gestation. Weight of control sows increased from 817 to 902 g (P less than 0.01) and pregnant sows from 810 to 1,251 g (P less than 0.01). LV weights were not different. When indexed for maternal weight minus uterus and contents, pregnancy produced increases in O2 consumption, +48% (P less than 0.01); cardiac output, +32% (P less than 0.05); and stroke volume, +46% (P less than 0.025). Passive LV pressure-volume curves (dP/dV) were shifted to the right (P less than 0.025), but dP/dV at constant pressure was unchanged. Using a thin-walled spherical model, elastic modulus at constant stress was not different. The percent LV inter- and intracellular volumes and myocyte myofibril and organelle volumes were unchanged during pregnancy. In the guinea pig, pregnancy increases LV output, stroke volume, and size without changes in LV mass, morphometry, or elastic modulus.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume246
Issue number1 Pt 2
StatePublished - Jan 1984
Externally publishedYes

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Guinea Pigs
Ventricular Pressure
Pregnancy
Weights and Measures
Elastic Modulus
Stroke Volume
Organelle Size
Hemodynamics
Myofibrils
Cardiac Output
Muscle Cells
Uterus
Mothers
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morton, M., Tsang, H., Hohimer, A. R., Ross, D., Thornburg, K., Faber, J., & Metcalfe, J. (1984). Left ventricular size, output, and structure during guinea pig pregnancy. The American journal of physiology, 246(1 Pt 2).

Left ventricular size, output, and structure during guinea pig pregnancy. / Morton, M.; Tsang, H.; Hohimer, Alan (Roger); Ross, D.; Thornburg, Kent; Faber, J.; Metcalfe, J.

In: The American journal of physiology, Vol. 246, No. 1 Pt 2, 01.1984.

Research output: Contribution to journalArticle

Morton, M, Tsang, H, Hohimer, AR, Ross, D, Thornburg, K, Faber, J & Metcalfe, J 1984, 'Left ventricular size, output, and structure during guinea pig pregnancy.', The American journal of physiology, vol. 246, no. 1 Pt 2.
Morton, M. ; Tsang, H. ; Hohimer, Alan (Roger) ; Ross, D. ; Thornburg, Kent ; Faber, J. ; Metcalfe, J. / Left ventricular size, output, and structure during guinea pig pregnancy. In: The American journal of physiology. 1984 ; Vol. 246, No. 1 Pt 2.
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