Left ventricular function in normal newborn infants and asymptomatic infants with neonatal polycythemia

Daniel J. Murphy, Mark Reller, Richard A. Meyer, Samuel Kaplan

Research output: Contribution to journalArticle

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Abstract

Digitized M-mode echocardiography was used to evaluate left ventricular (LV) function in normal neonates and to document subtle abnormalities of LV function in 19 asymptomatic newborn infants with polycythemia and hyperiviscosity. Echocardiograms were performed before and after partial exchange transfusion and at 48 hours of age. Results were compared to those obtained from analysis of echocardiograms from 18 normal infants with normal hematocrift at 12 and 48 hours of age. In the normal group there were no differences between the digitized indices of LV function at 12 hours and those at 48 hours of age. In the polycythemic group, prior to hemodilution, the peak rate of LV emptying was low compared to normal values (-3.1 ± 0.7 sec-1 vs -3.6 ± 1.0 sec-1, p <0.05) and normalized following the procedure to -3.7 ± 1.3 sec-1, The peak rate of left ventricular posterior wall (LVPW) thickening also increased following partial exchange transfusion (3.2 ± 0.6 sec-1 to 3.7 ± 1.0 sec-1, p <0.05). At 48 hours of age peak rates of change for the left ventricle (-2.9 ± 0.8) and LVPW (3.0 ± 0.7) were abnormally low in the polycythemic infants, all of whom had undergone partial exchange transfusion. Also, at 48 hours, the LVPW time to peak rate of thickening and time to the end of thicking were prolonged. In addition, the peak rate of LV filling in diastole was low in the polycythemic group (3.0 ± 0.9 sec-1 vs 3.9 ± 1.3 sec-1, p <0.05). Despite neonatal circulatory changes, digitized indices of LV function remain constant after 12 hours of age in normal infants. Newborn infants with polycythemia treated by partial exchange transfusion appear to have abnormalities of LV function at 48 hours of age. The pathogenesis and significance of the observed abnormalities remain unclear.

Original languageEnglish (US)
Pages (from-to)542-547
Number of pages6
JournalAmerican Heart Journal
Volume112
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

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Polycythemia
Left Ventricular Function
Newborn Infant
Hemodilution
Diastole
Heart Ventricles
Echocardiography
Reference Values

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Left ventricular function in normal newborn infants and asymptomatic infants with neonatal polycythemia. / Murphy, Daniel J.; Reller, Mark; Meyer, Richard A.; Kaplan, Samuel.

In: American Heart Journal, Vol. 112, No. 3, 1986, p. 542-547.

Research output: Contribution to journalArticle

Murphy, Daniel J. ; Reller, Mark ; Meyer, Richard A. ; Kaplan, Samuel. / Left ventricular function in normal newborn infants and asymptomatic infants with neonatal polycythemia. In: American Heart Journal. 1986 ; Vol. 112, No. 3. pp. 542-547.
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abstract = "Digitized M-mode echocardiography was used to evaluate left ventricular (LV) function in normal neonates and to document subtle abnormalities of LV function in 19 asymptomatic newborn infants with polycythemia and hyperiviscosity. Echocardiograms were performed before and after partial exchange transfusion and at 48 hours of age. Results were compared to those obtained from analysis of echocardiograms from 18 normal infants with normal hematocrift at 12 and 48 hours of age. In the normal group there were no differences between the digitized indices of LV function at 12 hours and those at 48 hours of age. In the polycythemic group, prior to hemodilution, the peak rate of LV emptying was low compared to normal values (-3.1 ± 0.7 sec-1 vs -3.6 ± 1.0 sec-1, p <0.05) and normalized following the procedure to -3.7 ± 1.3 sec-1, The peak rate of left ventricular posterior wall (LVPW) thickening also increased following partial exchange transfusion (3.2 ± 0.6 sec-1 to 3.7 ± 1.0 sec-1, p <0.05). At 48 hours of age peak rates of change for the left ventricle (-2.9 ± 0.8) and LVPW (3.0 ± 0.7) were abnormally low in the polycythemic infants, all of whom had undergone partial exchange transfusion. Also, at 48 hours, the LVPW time to peak rate of thickening and time to the end of thicking were prolonged. In addition, the peak rate of LV filling in diastole was low in the polycythemic group (3.0 ± 0.9 sec-1 vs 3.9 ± 1.3 sec-1, p <0.05). Despite neonatal circulatory changes, digitized indices of LV function remain constant after 12 hours of age in normal infants. Newborn infants with polycythemia treated by partial exchange transfusion appear to have abnormalities of LV function at 48 hours of age. The pathogenesis and significance of the observed abnormalities remain unclear.",
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