Left and right ventricular diastolic function in adults with surgically repaired tetralogy of fallot: A multi-institutional study

Jamil A. Aboulhosn, Gentian Lluri, Michelle Z. Gurvitz, Paul Khairy, François Pierre Mongeon, Joseph Kay, Anne Marie Valente, Michael G. Earing, Alexander R. Opotowsky, George Lui, Deborah R. Gersony, Stephen Cook, John Child, Jennifer Ting, Gary Webb, Michael Landzberg, Craig Broberg

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Background: Our purpose was to assess the prevalence and clinical implications of left ventricular (LV) and right ventricular (RV) diastolic dysfunction (DD) in patients with repaired tetralogy of Fallot (TOF). Methods: Adults with repaired TOF at 11 North American congenital heart disease centres were included. Of 556 patients analyzed, 325 had sufficient Doppler data to evaluate for LV DD, defined as mitral lateral e' <10 cm/s and E/e' ratio ≥ 9. Abnormal RV diastolic function was defined as tricuspid E/A ratio of 0.8 to 2.1 with E/e' ratio ≥ 6 or a tricuspid ratio E/A ≥ 2.1 with a deceleration time <120 milliseconds, and 105 patients were found to have sufficient Doppler data. Results: Abnormal LV diastolic Doppler indices were prevalent in 13.8% and associated with hypertension, dyslipidemia, 3 or more cardiac operations, and a history of ventricular tachycardia. Abnormal RV indices were prevalent in 52.4% and associated with hypertension, dyslipidemia, diabetes mellitus, and 3 or more cardiac operations. Ventricular tachycardia was more common in those with abnormal RV diastolic function. Conclusion: Further prospective studies are needed to evaluate these associations with DD and the impact of treatment risk factors on diastolic function and arrhythmia burden.

    Original languageEnglish (US)
    Pages (from-to)866-872
    Number of pages7
    JournalCanadian Journal of Cardiology
    Volume29
    Issue number7
    DOIs
    StatePublished - Jul 2013

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    Right Ventricular Function
    Tetralogy of Fallot
    Ventricular Tachycardia
    Dyslipidemias
    Hypertension
    Right Ventricular Dysfunction
    Deceleration
    Left Ventricular Dysfunction
    Cardiac Arrhythmias
    Heart Diseases
    Diabetes Mellitus
    Prospective Studies
    Therapeutics

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Left and right ventricular diastolic function in adults with surgically repaired tetralogy of fallot : A multi-institutional study. / Aboulhosn, Jamil A.; Lluri, Gentian; Gurvitz, Michelle Z.; Khairy, Paul; Mongeon, François Pierre; Kay, Joseph; Valente, Anne Marie; Earing, Michael G.; Opotowsky, Alexander R.; Lui, George; Gersony, Deborah R.; Cook, Stephen; Child, John; Ting, Jennifer; Webb, Gary; Landzberg, Michael; Broberg, Craig.

    In: Canadian Journal of Cardiology, Vol. 29, No. 7, 07.2013, p. 866-872.

    Research output: Contribution to journalArticle

    Aboulhosn, JA, Lluri, G, Gurvitz, MZ, Khairy, P, Mongeon, FP, Kay, J, Valente, AM, Earing, MG, Opotowsky, AR, Lui, G, Gersony, DR, Cook, S, Child, J, Ting, J, Webb, G, Landzberg, M & Broberg, C 2013, 'Left and right ventricular diastolic function in adults with surgically repaired tetralogy of fallot: A multi-institutional study', Canadian Journal of Cardiology, vol. 29, no. 7, pp. 866-872. https://doi.org/10.1016/j.cjca.2012.11.003
    Aboulhosn, Jamil A. ; Lluri, Gentian ; Gurvitz, Michelle Z. ; Khairy, Paul ; Mongeon, François Pierre ; Kay, Joseph ; Valente, Anne Marie ; Earing, Michael G. ; Opotowsky, Alexander R. ; Lui, George ; Gersony, Deborah R. ; Cook, Stephen ; Child, John ; Ting, Jennifer ; Webb, Gary ; Landzberg, Michael ; Broberg, Craig. / Left and right ventricular diastolic function in adults with surgically repaired tetralogy of fallot : A multi-institutional study. In: Canadian Journal of Cardiology. 2013 ; Vol. 29, No. 7. pp. 866-872.
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    AU - Khairy, Paul

    AU - Mongeon, François Pierre

    AU - Kay, Joseph

    AU - Valente, Anne Marie

    AU - Earing, Michael G.

    AU - Opotowsky, Alexander R.

    AU - Lui, George

    AU - Gersony, Deborah R.

    AU - Cook, Stephen

    AU - Child, John

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    AU - Webb, Gary

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