LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

Yoko Yamakoshi, Hui Qiao, Andrew N. Lowell, Mark Woods, Betty Paulose, Yuka Nakao, Hualei Zhang, Ting Liu, Sissel Lund-Katz, Rong Zhou

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.

Original languageEnglish (US)
Pages (from-to)8835-8837
Number of pages3
JournalChemical Communications
Volume47
Issue number31
DOIs
StatePublished - Aug 21 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Yamakoshi, Y., Qiao, H., Lowell, A. N., Woods, M., Paulose, B., Nakao, Y., Zhang, H., Liu, T., Lund-Katz, S., & Zhou, R. (2011). LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models. Chemical Communications, 47(31), 8835-8837. https://doi.org/10.1039/c1cc10924c