LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA

Peter S. Spencer, Albert Ludolph, M. P. Dwivedi, Dwijendra N. Roy, Jacques Hugon, H. H. Schaumburg

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

Lathyrism, a form of motoneurone disease induced by excessive consumption of the legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man.

Original languageEnglish (US)
Pages (from-to)1066-1067
Number of pages2
JournalThe Lancet
Volume328
Issue number8515
DOIs
StatePublished - Nov 8 1986

ASJC Scopus subject areas

  • Medicine(all)

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    Spencer, P. S., Ludolph, A., Dwivedi, M. P., Roy, D. N., Hugon, J., & Schaumburg, H. H. (1986). LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA. The Lancet, 328(8515), 1066-1067. https://doi.org/10.1016/S0140-6736(86)90468-X