LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA

Peter S. Spencer, Albert Ludolph, M. P. Dwivedi, Dwijendra N. Roy, Jacques Hugon, H. H. Schaumburg

Research output: Contribution to journalArticlepeer-review

308 Scopus citations

Abstract

Lathyrism, a form of motoneurone disease induced by excessive consumption of the legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man.

Original languageEnglish (US)
Pages (from-to)1066-1067
Number of pages2
JournalThe Lancet
Volume328
Issue number8515
DOIs
StatePublished - Nov 8 1986

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA'. Together they form a unique fingerprint.

Cite this