Lateral, but not medial, frontal lesions impair fixed ratio performance in rats

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Preoperatively, male hooded rats were reduced to 85% of their free-feeding weight, and trained to receive food reinforcement on a fixed ratio 32 schedule in standard operant chambers. When response rates stabilized, the rats were randomly assigned to one of the following surgical treatments: lateral frontal ablation, medial frontal ablation, or sham operate control (N=6/group). On the day following surgery, and continuing for a total of 15 postoperative days, the rats were retested on FR32. Lateral frontal lesions produced a dramatic reduction in response rate, while medial frontal lesions produced only a mild and transient effect. The sham operative procedure did not influence performance. These results suggest a dissociation of motor and associative functions in the frontal cortex of the rat and support anatomical evidence demonstrating this division.

Original languageEnglish (US)
Pages (from-to)625-627
Number of pages3
JournalPhysiology and Behavior
Volume24
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Operative Surgical Procedures
Frontal Lobe
Ambulatory Surgical Procedures
Appointments and Schedules
Weights and Measures
Food

Keywords

  • Fixed ratio
  • Lateral frontal cortex
  • Medial frontal cortex
  • Motor cortex
  • Rats

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Lateral, but not medial, frontal lesions impair fixed ratio performance in rats. / Numan, Robert; Grant, Kathleen (Kathy).

In: Physiology and Behavior, Vol. 24, No. 3, 1980, p. 625-627.

Research output: Contribution to journalArticle

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