Late-onset Becker muscular dystrophy: Refining the clinical features and electrophysiological findings

Tania Beltran Papsdorf, James F. Howard, Nizar Chahin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The aim of this study was to characterize a unique distribution of muscle involvement in sporadic Becker muscle dystrophy (BMD). Methods: Retrospective chart review, clinical examination, electrophysiological studies, cardiac testing, and genetic testing were performed in 5 patients. Results: Predominant weakness and atrophy of biceps brachii, hip adduction, and quadriceps muscles was noted along with calf and extensor forearm hypertrophy. Finger flexor muscles were severely weak in 3 of 5 patients, a feature that could lead to a misdiagnosis of inclusion body myositis. Creatinine kinase was only mildly elevated in most patients. Electromyography was abnormal in all patients. Muscle biopsy in 1 patient demonstrated normal immunostaining for dystrophin. Conclusions: We found a unique and uniform distribution of muscle involvement in 5 sporadic cases of BMD. Recognizing these features is important for differentiating it from other myopathies that may have similar features and avoids unnecessary invasive procedures such as muscle biopsy.

Original languageEnglish (US)
Pages (from-to)885-887
Number of pages3
JournalMuscle and Nerve
Volume52
Issue number5
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Fingerprint

Duchenne Muscular Dystrophy
Muscles
Inclusion Body Myositis
Biopsy
Unnecessary Procedures
Dystrophin
Quadriceps Muscle
Genetic Testing
Electromyography
Muscular Diseases
Diagnostic Errors
Forearm
Hypertrophy
Fingers
Atrophy
Hip
Creatinine
Phosphotransferases

Keywords

  • Becker muscular dystrophy
  • EMG
  • Finger flexor weakness
  • Muscle biopsy
  • Muscle disease [185]
  • Quadriceps weakness

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology
  • Medicine(all)

Cite this

Late-onset Becker muscular dystrophy : Refining the clinical features and electrophysiological findings. / Beltran Papsdorf, Tania; Howard, James F.; Chahin, Nizar.

In: Muscle and Nerve, Vol. 52, No. 5, 01.11.2015, p. 885-887.

Research output: Contribution to journalArticle

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