Late infection in cardiac allograft recipients: Profiles, incidence, and outcome

J. D. Hosenpud, R. E. Hershberger, George Pantely, Douglas Norman, H. Hovaguimian, A. Cobanoglu, Albert Starr

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Infection continues to cause substantial morbidity and mortality after heart transplantation. Studies focusing on this problem have concentrated on the early posttransplant period, and it is uncertain to what extent infection continues to add to morbidity later after transplantation. Fifty-four patients surviving at least 1 year after heart transplantation made up the study population in this study, and they were surveyed for infections beyond 1 year. In this group there were 15 infections, an incidence of 0.3 infections per patient or 0.016 infections per patient-month of follow-up. Only nine of these infections necessitated hospitalization; two, however, were fatal. Actuarial risk of all late infections and late infections necessitating hospitalization was 13% and 6%, respectively, at 2 years. As expected, bacterial infections made up the largest group (60%), followed by viral disease (27%). Two patients had pulmonary infections, one with Aspergillus and one with Pneumocystis. These data demonstrate that although rates of infection in heart recipients continue to exceed those in the general population, the rates are considerably lower than those in what is seen early after heart transplantation. Despite this, the more unusual infectious agents associated with immune compromise continue to be present.

Original languageEnglish (US)
Pages (from-to)380-386
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume10
Issue number3
StatePublished - 1991

Fingerprint

Allografts
Incidence
Infection
Heart Transplantation
Hospitalization
Pneumocystis
Morbidity
Virus Diseases
Aspergillus
Bacterial Infections
Population
Transplantation
Lung
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Hosenpud, J. D., Hershberger, R. E., Pantely, G., Norman, D., Hovaguimian, H., Cobanoglu, A., & Starr, A. (1991). Late infection in cardiac allograft recipients: Profiles, incidence, and outcome. Journal of Heart and Lung Transplantation, 10(3), 380-386.

Late infection in cardiac allograft recipients : Profiles, incidence, and outcome. / Hosenpud, J. D.; Hershberger, R. E.; Pantely, George; Norman, Douglas; Hovaguimian, H.; Cobanoglu, A.; Starr, Albert.

In: Journal of Heart and Lung Transplantation, Vol. 10, No. 3, 1991, p. 380-386.

Research output: Contribution to journalArticle

Hosenpud, JD, Hershberger, RE, Pantely, G, Norman, D, Hovaguimian, H, Cobanoglu, A & Starr, A 1991, 'Late infection in cardiac allograft recipients: Profiles, incidence, and outcome', Journal of Heart and Lung Transplantation, vol. 10, no. 3, pp. 380-386.
Hosenpud JD, Hershberger RE, Pantely G, Norman D, Hovaguimian H, Cobanoglu A et al. Late infection in cardiac allograft recipients: Profiles, incidence, and outcome. Journal of Heart and Lung Transplantation. 1991;10(3):380-386.
Hosenpud, J. D. ; Hershberger, R. E. ; Pantely, George ; Norman, Douglas ; Hovaguimian, H. ; Cobanoglu, A. ; Starr, Albert. / Late infection in cardiac allograft recipients : Profiles, incidence, and outcome. In: Journal of Heart and Lung Transplantation. 1991 ; Vol. 10, No. 3. pp. 380-386.
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