Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine

B. H. Strauss, R. A. Wilson, R. Van Houten, R. J. Van Suylen, Edward Murphy, J. Escaned, P. D. Verdouw, P. W. Serruys, W. J. Van der Giessen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Balloon angioplasty damages endothelial cells and stimulates smooth muscle cell proliferation. The effects of local cytotoxic drug therapy on formation of neointima and late endothelial function are not known. This study was designed to determine whether direct infusion of mitomycin C via a microporous balloon catheter could significantly reduce formation of neointima after angioplasty. Furthermore, we investigated whether endothelial cell function is normal 7 weeks after the initial microporous angioplasty procedure. Methods: In 34 New Zealand white rabbits, bilateral external iliac arteries underwent balloon angioplasty, followed by either high-dose (0.66 mg/kg) or low-dose (0.025 mg/kg) mitomycin C in one iliac artery and saline infusion in the contralateral artery, and a control group was given saline in both vessels. Formation of neointima was measured in the iliac arteries after 7 weeks by morphometry. Before sacrifice of 17 'angioplasty' rabbits and three undamaged rabbits, graded doses of acetylcholine and isosorbide dinitrate were infused in the distal aorta, and the iliac artery diameter was measured by computerized quantitative angiography. Results: No significant differences in the absolute area of the intima or the intima: media ratio were demonstrated between control arteries and arteries that were directly infused with either high-dose or low-dose mitomycin. However, within the high-dose group, the mitomycin-treated vessel had a significantly lesser extent of formation of intimal hyperplasia (0.17±0.03 versus 0.27±0.03 mm2, P

Original languageEnglish (US)
Pages (from-to)633-641
Number of pages9
JournalCoronary Artery Disease
Volume5
Issue number7
StatePublished - 1994
Externally publishedYes

Fingerprint

Neointima
Iliac Artery
Mitomycin
Acetylcholine
Angioplasty
Balloon Angioplasty
Arteries
Rabbits
Endothelial Cells
Tunica Intima
Isosorbide Dinitrate
Smooth Muscle Myocytes
Hyperplasia
Aorta
Angiography
Catheters
Cell Proliferation
Drug Therapy
Control Groups

Keywords

  • angioplasty
  • antiproliferatives
  • endothelial function
  • neointimal hyperplasia
  • restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Strauss, B. H., Wilson, R. A., Van Houten, R., Van Suylen, R. J., Murphy, E., Escaned, J., ... Van der Giessen, W. J. (1994). Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine. Coronary Artery Disease, 5(7), 633-641.

Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine. / Strauss, B. H.; Wilson, R. A.; Van Houten, R.; Van Suylen, R. J.; Murphy, Edward; Escaned, J.; Verdouw, P. D.; Serruys, P. W.; Van der Giessen, W. J.

In: Coronary Artery Disease, Vol. 5, No. 7, 1994, p. 633-641.

Research output: Contribution to journalArticle

Strauss, BH, Wilson, RA, Van Houten, R, Van Suylen, RJ, Murphy, E, Escaned, J, Verdouw, PD, Serruys, PW & Van der Giessen, WJ 1994, 'Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine', Coronary Artery Disease, vol. 5, no. 7, pp. 633-641.
Strauss, B. H. ; Wilson, R. A. ; Van Houten, R. ; Van Suylen, R. J. ; Murphy, Edward ; Escaned, J. ; Verdouw, P. D. ; Serruys, P. W. ; Van der Giessen, W. J. / Late effects of locally delivered mitomycin C on formation of neointima and on vasomotor response to acetylcholine. In: Coronary Artery Disease. 1994 ; Vol. 5, No. 7. pp. 633-641.
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AU - Wilson, R. A.

AU - Van Houten, R.

AU - Van Suylen, R. J.

AU - Murphy, Edward

AU - Escaned, J.

AU - Verdouw, P. D.

AU - Serruys, P. W.

AU - Van der Giessen, W. J.

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