Laryngeal chemoreflex: Anatomic and physiologic study by use of the superior laryngeal nerve in the piglet

George S. Goding, Mark A. Richardson, Ronald E. Trachy

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The laryngeal chemoreflex (LCR) was investigated in 21 piglets (ages 6 to 80 days old) with the use of physiologic and histologic techniques. The central projection of the superior laryngeal nerve (SLN) was determined in 14 animals by use of horseradish peroxidase-wheat germ agglutinin. Ipsilateral labeling of the solitary tract nucleus was seen. The caudal extent of the labeling varied with age. Sensory labeling of the nucleus ambiguus was present bilaterally in three younger animals and unilaterally in older piglets. Bilateral labeling of the nucleus dorsomedialis was seen in all ages. Apneic and cardiovascular response to water stimulation of laryngeal mucosa and the laryngeal adductor reflex (LAR) were examined in 16 piglets. Blunting of the apneic and cardiovascular response was seen after sacrifice of a single SLN. Hypoxia did not significantly affect the LAR or apnea duration in animals with only one intact SLN. A contralateral LAR was found in younger animals. Relevance to the LCR is also discussed.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
JournalOtolaryngology-Head and Neck Surgery
Volume97
Issue number1
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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