Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

Wei Zhao, Jun Li, Mei Ju M. Chen, Yikai Luo, Zhenlin Ju, Nicole K. Nesser, Katie Johnson-Camacho, Christopher T. Boniface, Yancey Lawrence, Nupur T. Pande, Michael A. Davies, Meenhard Herlyn, Taru Muranen, Ioannis K. Zervantonakis, Erika von Euw, Andre Schultz, Shwetha V. Kumar, Anil Korkut, Paul T. Spellman, Rehan AkbaniDennis J. Slamon, Joe W. Gray, Joan S. Brugge, Yiling Lu, Gordon B. Mills, Han Liang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein responses provides better prediction of drug sensitivity and insights into drug-resistance mechanisms and combination therapies.

Original languageEnglish (US)
Pages (from-to)829-843.e4
JournalCancer Cell
Volume38
Issue number6
DOIs
StatePublished - Dec 14 2020

Keywords

  • biomarker
  • cancer signaling pathway
  • drug response
  • protein array

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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