Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men

E. Grundberg, E. M. Lau, M. Lorentzson, M. Karlsson, A. Holmberg, L. Groop, D. Mellström, Eric Orwoll, H. Mallmin, C. Ohlsson, Ö Ljunggren, K. Åkesson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Summary: Herein we investigated the association between polymorphisms in the LRP5 gene and bone phenotypes and fractures in three large male cohorts based on the rationale that mutations in LRP5 cause severe bone phenotypes. Results showed an association of the Val667Met SNP with spine BMD in 3,800 young and elderly men. Introduction: The low-density lipoprotein receptor-related protein 5 (LRP5)-Wnt signalling system is of importance for regulating osteoblastic activity, which became clear after findings that inactivating mutations in LRP5 cause osteoporosis. The overall aim of this study was to investigate the association between polymorphisms in the LRP5 gene and bone mineral density (BMD) in three large cohorts of young and elderly men. Methods: The cohorts used were MrOS Sweden (n=3014, aged 69-81 years) and MrOs Hong Kong (n=2000, aged >65 years) and the Swedish GOOD study (n=1068, aged 18-20 years). The polymorphisms Val667Met and Ala1330Val were genotyped using a TaqMan assay. Results: When combining the data from the Swedish cohorts in a meta-analysis (n=3,800), men carrying the 667Met-allele had 3% lower BMD at lumbar spine compared with non-carriers (p

Original languageEnglish (US)
Pages (from-to)829-837
Number of pages9
JournalOsteoporosis International
Volume19
Issue number6
DOIs
StatePublished - Jun 2008

Fingerprint

Low Density Lipoprotein Receptor-Related Protein-5
Bone Fractures
Phenotype
Bone Density
Genes
Spine
Mutation
Hong Kong
Sweden
Osteoporosis
Single Nucleotide Polymorphism
Meta-Analysis
Alleles
Bone and Bones

Keywords

  • BMD
  • Fracture risk
  • LRP5
  • Polymorphism
  • Population-based

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grundberg, E., Lau, E. M., Lorentzson, M., Karlsson, M., Holmberg, A., Groop, L., ... Åkesson, K. (2008). Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. Osteoporosis International, 19(6), 829-837. https://doi.org/10.1007/s00198-007-0512-z

Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. / Grundberg, E.; Lau, E. M.; Lorentzson, M.; Karlsson, M.; Holmberg, A.; Groop, L.; Mellström, D.; Orwoll, Eric; Mallmin, H.; Ohlsson, C.; Ljunggren, Ö; Åkesson, K.

In: Osteoporosis International, Vol. 19, No. 6, 06.2008, p. 829-837.

Research output: Contribution to journalArticle

Grundberg, E, Lau, EM, Lorentzson, M, Karlsson, M, Holmberg, A, Groop, L, Mellström, D, Orwoll, E, Mallmin, H, Ohlsson, C, Ljunggren, Ö & Åkesson, K 2008, 'Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men', Osteoporosis International, vol. 19, no. 6, pp. 829-837. https://doi.org/10.1007/s00198-007-0512-z
Grundberg, E. ; Lau, E. M. ; Lorentzson, M. ; Karlsson, M. ; Holmberg, A. ; Groop, L. ; Mellström, D. ; Orwoll, Eric ; Mallmin, H. ; Ohlsson, C. ; Ljunggren, Ö ; Åkesson, K. / Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. In: Osteoporosis International. 2008 ; Vol. 19, No. 6. pp. 829-837.
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