Large-cell hematolymphoid neoplasms of uncertain lineage

Lawrence M. Weiss, Louis Picker, Cedith M. Copenhaver, Roger A. Warnke, Jeffrey Sklar

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

In almost every large study attempting to characterize non-Hodgkin's lymphomas, there is a small subset of tumors for which the lineage remains poorly defined. The investigators studied a series of 20 hematolymphoid neoplasms that could not be clearly assigned to the B or T cell lineage by phenotypic criteria. Histologically, 12 cases had an appearance suggesting a histiocytic origin, seven cases resembled a pleomorphic immunoblastic lymphoma, and one had a sarcomatoid appearance. By immunologic studies, a variety of B cell, T cell, and monocyte/ macrophage markers were expressed on the neoplasms, often with coexpression of markers for different lineages. Twelve cases expressed the Ki-1 antigen. In immunogenotyping studies of T cell receptor (TCR) and immunoglobulin genes, 13 cases showed clonal rearrangements of the β or γ TCR gene; one of these cases also had clonal rearrangements of a light chain immunoglobulin gene. Seven cases showed a germline configuration with all combinations of probes and enzymes used. We conclude that a small subset of hematolymphoid neoplasms shows a pattern of diverse immunologic marker expression that does not appear to reflect normal differentiation. However, a majority of these cases contain clonal TCR gene rearrangements, suggesting a frequent relationship to the T lineage.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalHuman Pathology
Volume19
Issue number8
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

T-Cell Receptor Genes
Non-Hodgkin's Lymphoma
Neoplasms
CD30 Antigens
Immunoglobulin Light Chain Genes
B-Lymphocytes
T-Lymphocyte Gene Rearrangement
T-Lymphocytes
Immunoglobulin Genes
Cell Lineage
Monocytes
Biomarkers
Macrophages
Research Personnel
Enzymes

Keywords

  • histiocytic neoplasms
  • Ki-1 lymphoma
  • malignant lymphoma
  • non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Weiss, L. M., Picker, L., Copenhaver, C. M., Warnke, R. A., & Sklar, J. (1988). Large-cell hematolymphoid neoplasms of uncertain lineage. Human Pathology, 19(8), 967-973. https://doi.org/10.1016/S0046-8177(88)80014-5

Large-cell hematolymphoid neoplasms of uncertain lineage. / Weiss, Lawrence M.; Picker, Louis; Copenhaver, Cedith M.; Warnke, Roger A.; Sklar, Jeffrey.

In: Human Pathology, Vol. 19, No. 8, 1988, p. 967-973.

Research output: Contribution to journalArticle

Weiss, LM, Picker, L, Copenhaver, CM, Warnke, RA & Sklar, J 1988, 'Large-cell hematolymphoid neoplasms of uncertain lineage', Human Pathology, vol. 19, no. 8, pp. 967-973. https://doi.org/10.1016/S0046-8177(88)80014-5
Weiss, Lawrence M. ; Picker, Louis ; Copenhaver, Cedith M. ; Warnke, Roger A. ; Sklar, Jeffrey. / Large-cell hematolymphoid neoplasms of uncertain lineage. In: Human Pathology. 1988 ; Vol. 19, No. 8. pp. 967-973.
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