Laminins of the neuromuscular system

Bruce Patton

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The mammalian neuromuscular system expresses seven laminin genes (α1, α2, α4, α5, β1, β2, and γ1), produces seven isoforms of the laminin trimer (laminins 1, 2, 4, 8, 9, 10, and 11), and distributes these trimers to at least seven distinct basal laminae (perineurial, endoneurial, terminal Schwann cell, myotendinous junction, synaptic cleft, synaptic fold, and extrajunctional muscle). The patterns of expression, assembly, and distribution are regulated during development, and primary and secondary changes in laminin expression occur in several neuromuscular genetic disorders. Functional studies using knockout and transgenic mice, and purified laminins and cell types, demonstrate that laminins are required components of basal laminae in the neuromuscular system. Collectively, laminins have both structural and signaling functions; individually, laminin isoforms have unique roles in regulating the behavior of nerve, muscle, and Schwann cell. Among them, laminin-2 (α2β1γ1) plays an important structural role in supporting the muscle plasma membrane, laminin-4 regulates adhesion and differentiation of the myotendinous junction, and laminin-11 regulates nerve terminal differentiation and Schwann cell motility. Together, these observations reveal remarkable diversity in the formation and function of laminins and basal laminae, and suggest avenues for addressing some neuromuscular diseases. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)247-261
Number of pages15
JournalMicroscopy Research and Technique
Volume51
Issue number3
DOIs
StatePublished - Nov 1 2000

Fingerprint

laminin
Laminin
Muscle
Cells
nerves
trimers
muscles
knockout mice
Cell membranes
Schwann Cells
muscle cells
Schwann cells
locomotion
Basement Membrane
laminae (animals)
Adhesion
Genes
genes
mice
adhesion

Keywords

  • Basal lamina
  • Muscular dystrophy
  • Myotendinous junction
  • Neuromuscular junction
  • Synapse formation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Laminins of the neuromuscular system. / Patton, Bruce.

In: Microscopy Research and Technique, Vol. 51, No. 3, 01.11.2000, p. 247-261.

Research output: Contribution to journalArticle

Patton, Bruce. / Laminins of the neuromuscular system. In: Microscopy Research and Technique. 2000 ; Vol. 51, No. 3. pp. 247-261.
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