Laminins α2 and α4 in Pancreatic Acinar Basement Membranes Are Required for Basal Receptor Localization

Jeffrey H. Miner, Cong Li, Bruce L. Patton

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Basement membranes (BMs) are thin layers of extracellular matrix (ECM) found at the basal surface of many cell types, including epithelial cells. BMs present growth, differentiation, and anti-apoptotic signals and provide structural support to cells, compartmentalize tissues, and serve as filters. The structure and function of BMs depend on their complement of laminins, a family of αβγ heterotrimeric glycoproteins. We found that laminins containing the α2 and α4 chains are the major laminins in pancreatic acinar BMs. Importantly, these laminins were required for proper basal localization on acinar cells of two laminin receptors, dystroglycan and integrin α6β4.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Volume52
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Dystroglycan
  • Integrin
  • Laminin
  • Merosin
  • Pancreas

ASJC Scopus subject areas

  • Anatomy
  • Histology

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