Laminins α2 and α4 in Pancreatic Acinar Basement Membranes Are Required for Basal Receptor Localization

Jeffrey H. Miner, Cong Li, Bruce Patton

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Basement membranes (BMs) are thin layers of extracellular matrix (ECM) found at the basal surface of many cell types, including epithelial cells. BMs present growth, differentiation, and anti-apoptotic signals and provide structural support to cells, compartmentalize tissues, and serve as filters. The structure and function of BMs depend on their complement of laminins, a family of αβγ heterotrimeric glycoproteins. We found that laminins containing the α2 and α4 chains are the major laminins in pancreatic acinar BMs. Importantly, these laminins were required for proper basal localization on acinar cells of two laminin receptors, dystroglycan and integrin α6β4.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Volume52
Issue number2
StatePublished - Feb 2004

Fingerprint

Laminin
Basement Membrane
Dystroglycans
Laminin Receptors
Acinar Cells
Integrins
Extracellular Matrix
Glycoproteins
Epithelial Cells
Growth

Keywords

  • Dystroglycan
  • Integrin
  • Laminin
  • Merosin
  • Pancreas

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Laminins α2 and α4 in Pancreatic Acinar Basement Membranes Are Required for Basal Receptor Localization. / Miner, Jeffrey H.; Li, Cong; Patton, Bruce.

In: Journal of Histochemistry and Cytochemistry, Vol. 52, No. 2, 02.2004, p. 153-156.

Research output: Contribution to journalArticle

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