Laminar analysis of the number of neurons, astrocytes, oligodendrocytes and microglia in the visual cortex (Area 17) of 3-month-old rhesus monkeys fed a human infant soy-protein formula with or without taurine supplementation from birth

Thomas Palackal, Mark Kujawa, Roger Moretz, Martha Neuringer, John Sturman

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The effect of taurine addition to a commercial (taurine-free) soy-protein formula on the development of the visual cortex has been examined in 3-month-old rhesus monkeys. The thickness, number of neurons, astrocytes, oligodendrocytes and microglia have been measured in the different laminae. There were no significant differences in cortical thickness, total number of neurons, astrocytes, oligodendrocytes, or microglia between the groups, but there were some significant differences in some laminae as well as some qualitative differences. The numerical density of neurons in layers IV-αt and V-2 was significantly greater in the taurine-supplemented monkeys than in those fed the taurine-free formula; the numerical density of astrocytes in layer IV-A was significantly greater and in layer IV-α was significantly smaller in the taurine-supplemented monkeys than in those fed the taurine-free formula. A number of other measurements in the two groups approached significance. These differences indicate that there are developmental disadvantages in the visual cortex of rhesus monkeys raised on a taurine-free human infant formula in addition to those previously reported.

    Original languageEnglish (US)
    Pages (from-to)20-33
    Number of pages14
    JournalDevelopmental Neuroscience
    Volume13
    Issue number1
    DOIs
    StatePublished - 1991

    Fingerprint

    Soybean Proteins
    Taurine
    Oligodendroglia
    Microglia
    Visual Cortex
    Macaca mulatta
    Astrocytes
    Parturition
    Neurons
    Haplorhini
    Infant Formula

    Keywords

    • Brain development
    • Formula infant
    • Nutrition infant
    • Quantitative morphometry
    • Taurine depletion
    • Visual cortex

    ASJC Scopus subject areas

    • Developmental Neuroscience
    • Neurology
    • Neuroscience(all)

    Cite this

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    abstract = "The effect of taurine addition to a commercial (taurine-free) soy-protein formula on the development of the visual cortex has been examined in 3-month-old rhesus monkeys. The thickness, number of neurons, astrocytes, oligodendrocytes and microglia have been measured in the different laminae. There were no significant differences in cortical thickness, total number of neurons, astrocytes, oligodendrocytes, or microglia between the groups, but there were some significant differences in some laminae as well as some qualitative differences. The numerical density of neurons in layers IV-αt and V-2 was significantly greater in the taurine-supplemented monkeys than in those fed the taurine-free formula; the numerical density of astrocytes in layer IV-A was significantly greater and in layer IV-α was significantly smaller in the taurine-supplemented monkeys than in those fed the taurine-free formula. A number of other measurements in the two groups approached significance. These differences indicate that there are developmental disadvantages in the visual cortex of rhesus monkeys raised on a taurine-free human infant formula in addition to those previously reported.",
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