There is an increased incidence of hematologic abnormalities in young stroke patients. The prothrombin gene G20210A mutation (PGM) is a newly described risk factor found in association with clotting disorders. Currently, a clear association of PGM with arterial stroke has not been described. This article examines the frequency of PGM in a consecutive series of young stroke patients. All patients who were 55 years of age or younger who were admitted to the Oregon Health Sciences University for arterial stroke between December 1, 1997 and August 31, 1998 were examined for the PGM. Plasma was analyzed at the Medical Genetics Center at Oregon Health Sciences University. We identified 42 young stroke patients with a mean age of 43 (range, 19 to 55); 48% were women. Thirty-eight patients had plasma tested for PGM. The cause of stroke in 6 patients (14%) was believed to be secondary to atherosclerosis, 4 (10%) had strokes caused by cardioembolism, 9 (21%) were lacunar, 5 (12%) were secondary to dissection, and 12 (28%) were idiopathic. No patient in the study carried the PGM. The defined frequency of PGM in our laboratory in the healthy population is 2.05%. We found no association of PGM with stroke in the 38 patients studied. PGM does not appear to be a risk factor for arterial stroke in this high-risk population. However, the small sample size warrants further study.
- Prothrombin gene mutation
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine