Lack of impact of therapy on extent of Barrett's esophagus in 67 patients

Richard E. Sampliner, Harinder S. Garewal, M. Brian Fennerty, Mikel Aickin

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

Sixty-seven patients with Barrett's esophagus have been prospectively followed over an average of 36 months (range 6 to 76 months) with standardized endoscopic observation and biopsies of the length of columnar epithelium. The initial length of Barrett's epithelium ranged from 1 to 16 cm, mean 5.5 cm. Specialized columnar epithelium was present in 64 of the 67 patients. Patients were treated predominantly with H2-receptor blocker therapy to relieve symptoms. Eighty-two percent of patients had less than a 1-cm change in length per year. The mean rate of change of length was -0.093 cm per year. These results confirm in a relatively large, prospective study that standard antireflux therapy for Barrett's esophagus does not result in consistent reduction in the extent of Barrett's epithelium over a three-year interval.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalDigestive diseases and sciences
Volume35
Issue number1
DOIs
StatePublished - Jan 1 1990

Keywords

  • Barrett's esophagus
  • therapy

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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