@article{1d00e8df3e7e462c8aef57dafe52b56c,
title = "Lack of Functional Immunoregulatory Cells in a Patient With Mycosis Fungoides and Circulating Sezary Cells: Brief Communication",
abstract = "Peripheral blood lymphocytes obtained at various intervals from normal individuals and from a patient with mycosis fungoides (MF) were cultured with phytohemagglutinin (PHA) for 3 days to activate suppressor cells. After being cultured, the PHA-treated cells were irradiated, washed, and then transferred to fresh medium with PHA. The PHA responsiveness of the cells from normal individuals was suppressed approximately 90% by autologous or normal allogeneic lymphocytes activated for 3 days with PHA, whereas the cells activated for 3 days with PHA from the patient with MF lacked the capacity to Inhibit the mitogenic response of autologous or allogeneic lymphocytes. These data suggest that this patient lacked suppressor T-cells that have a specificity for helper T-cells.-J Natl Cancer Inst 60: 1295-1299, 1978.",
author = "Vali Kermani-Arab and Roberts, {Janet L.} and Hanifin, {Jon M.} and Leslie, {Gerrie A.}",
note = "Funding Information: I Received August 12, 1977; accepted January 10, 1978. 2 Supported by the John A. Hartford Foundation, Inc. and the Veterans Administration Hospital of Portland. 3 Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Ponland, Oreg. 9720 I . 4 Present address: Institute of Biochemistry and Biophysics, School of Public Health and Institute of Public Health Research, University of Teheran, Teheran, Iran. S N. L. Tartar Research Fellow at the University of Oregon Health Sciences Center. 6 Department of Dermatology, University of Oregon Health Sciences Center. 7 Address reprint requests to Dr. Leslie. 8 We.thank Dr. Marvin Cuchens, Mr. Douglas Dawson, and Ms. Joanie Olson (Department of Microbiology and Immunology) for their valuable comments; Dr. Robert Amon (Department of Dermatology) for the hematologic studies and blood samples; and Mr. Victor Richenstein (Department of Microbiology and Immunology) for excellent technical assistance.",
year = "1978",
month = jun,
doi = "10.1093/jnci/60.6.1295",
language = "English (US)",
volume = "60",
pages = "1295--1299",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "6",
}