Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice

Shelly D. Dickinson, Elizabeth L. Lee, Kirsten Rindal, Christopher Cunningham

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rationale: Self-administration studies have suggested that dopamine (DA) is important for the reinforcing effects of ethanol. However, ethanol place conditioning studies have less consistently demonstrated a role for DA in conditioned place preference. Objectives: The purpose of the present study was to determine whether blockade of D1, D2 or D3 DA receptors would impact the expression of the conditioned place preference induced by ethanol in DBA/2J mice. Methods: Mice underwent an unbiased place conditioning procedure with 2 g/kg ethanol. Prior to the preference test, mice were injected i.p. with SCH23390 (0, 0.015 or 0.03 mg/kg), raclopride (0, 0.3 or 0.6 mg/kg) or U99194A (0, 10 or 20 mg/kg). Results: Ethanol produced a significant conditioned place preference that was not affected by any of the dopamine antagonists tested. Each of the antagonists decreased locomotor activity, though U99194A was minimally effective. Conclusions: These findings suggest that the conditioned reinforcing effects of ethanol in DBA/2J mice as assessed by place conditioning are mediated by non-dopaminergic mechanisms.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalPsychopharmacology
Volume165
Issue number3
StatePublished - Jan 2003

Fingerprint

Dopamine Receptors
Ethanol
Inbred DBA Mouse
Dopamine
Dopamine D3 Receptors
Raclopride
Dopamine D1 Receptors
Self Administration
Dopamine Antagonists
Dopamine D2 Receptors
Locomotion

Keywords

  • DBA/2J mice
  • Dopamine antagonists
  • Ethanol
  • Place conditioning
  • Raclopride
  • Reinforcement
  • SCH23390
  • U99194A

ASJC Scopus subject areas

  • Pharmacology

Cite this

Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. / Dickinson, Shelly D.; Lee, Elizabeth L.; Rindal, Kirsten; Cunningham, Christopher.

In: Psychopharmacology, Vol. 165, No. 3, 01.2003, p. 238-244.

Research output: Contribution to journalArticle

Dickinson, Shelly D. ; Lee, Elizabeth L. ; Rindal, Kirsten ; Cunningham, Christopher. / Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. In: Psychopharmacology. 2003 ; Vol. 165, No. 3. pp. 238-244.
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