Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation

Baldeep Wirk, Thomas R. Klumpp, John Ulicny, Jay H. Herman, James L. Gajewski, Mary E. Martin, Robert V B Emmons, Kenneth F. Mangan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation and should be a criterion for donor selection. STUDY DESIGN AND METHODS: To further evaluate this issue, 258 consecutive patients who underwent myeloablative or submyeloablative allogeneic hematopoietic stem cell transplantation at our institution were analyzed to determine the association between the Rh mismatch pattern and 5-year actuarial survival. Secondary endpoints analyzed were the association of donor-recipient Rh mismatch and event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), and incidence of chronic GVHD. RESULTS: In our analysis, there were no significant associations between donor-recipient Rh mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute GVHD, or incidence of chronic GVHD. On multivariate Cox proportional hazard analyses, the donor-recipient Rh mismatch pattern was not independently predictive of overall survival. CONCLUSION: Donor-recipient Rh mismatch is not a risk factor in allogeneic hematopoietic stem cell transplantation and does not affect transplant outcomes.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalTransfusion
Volume48
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Tissue Donors
Graft vs Host Disease
Survival
Incidence
Transplants
Disease-Free Survival
Donor Selection
Mortality

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Wirk, B., Klumpp, T. R., Ulicny, J., Herman, J. H., Gajewski, J. L., Martin, M. E., ... Mangan, K. F. (2008). Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation. Transfusion, 48(1), 163-168. https://doi.org/10.1111/j.1537-2995.2007.01501.x

Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation. / Wirk, Baldeep; Klumpp, Thomas R.; Ulicny, John; Herman, Jay H.; Gajewski, James L.; Martin, Mary E.; Emmons, Robert V B; Mangan, Kenneth F.

In: Transfusion, Vol. 48, No. 1, 01.2008, p. 163-168.

Research output: Contribution to journalArticle

Wirk, B, Klumpp, TR, Ulicny, J, Herman, JH, Gajewski, JL, Martin, ME, Emmons, RVB & Mangan, KF 2008, 'Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation', Transfusion, vol. 48, no. 1, pp. 163-168. https://doi.org/10.1111/j.1537-2995.2007.01501.x
Wirk, Baldeep ; Klumpp, Thomas R. ; Ulicny, John ; Herman, Jay H. ; Gajewski, James L. ; Martin, Mary E. ; Emmons, Robert V B ; Mangan, Kenneth F. / Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation. In: Transfusion. 2008 ; Vol. 48, No. 1. pp. 163-168.
@article{c73618475a384ae39388d83c6672748b,
title = "Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation",
abstract = "BACKGROUND: A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation and should be a criterion for donor selection. STUDY DESIGN AND METHODS: To further evaluate this issue, 258 consecutive patients who underwent myeloablative or submyeloablative allogeneic hematopoietic stem cell transplantation at our institution were analyzed to determine the association between the Rh mismatch pattern and 5-year actuarial survival. Secondary endpoints analyzed were the association of donor-recipient Rh mismatch and event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), and incidence of chronic GVHD. RESULTS: In our analysis, there were no significant associations between donor-recipient Rh mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute GVHD, or incidence of chronic GVHD. On multivariate Cox proportional hazard analyses, the donor-recipient Rh mismatch pattern was not independently predictive of overall survival. CONCLUSION: Donor-recipient Rh mismatch is not a risk factor in allogeneic hematopoietic stem cell transplantation and does not affect transplant outcomes.",
author = "Baldeep Wirk and Klumpp, {Thomas R.} and John Ulicny and Herman, {Jay H.} and Gajewski, {James L.} and Martin, {Mary E.} and Emmons, {Robert V B} and Mangan, {Kenneth F.}",
year = "2008",
month = "1",
doi = "10.1111/j.1537-2995.2007.01501.x",
language = "English (US)",
volume = "48",
pages = "163--168",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation

AU - Wirk, Baldeep

AU - Klumpp, Thomas R.

AU - Ulicny, John

AU - Herman, Jay H.

AU - Gajewski, James L.

AU - Martin, Mary E.

AU - Emmons, Robert V B

AU - Mangan, Kenneth F.

PY - 2008/1

Y1 - 2008/1

N2 - BACKGROUND: A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation and should be a criterion for donor selection. STUDY DESIGN AND METHODS: To further evaluate this issue, 258 consecutive patients who underwent myeloablative or submyeloablative allogeneic hematopoietic stem cell transplantation at our institution were analyzed to determine the association between the Rh mismatch pattern and 5-year actuarial survival. Secondary endpoints analyzed were the association of donor-recipient Rh mismatch and event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), and incidence of chronic GVHD. RESULTS: In our analysis, there were no significant associations between donor-recipient Rh mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute GVHD, or incidence of chronic GVHD. On multivariate Cox proportional hazard analyses, the donor-recipient Rh mismatch pattern was not independently predictive of overall survival. CONCLUSION: Donor-recipient Rh mismatch is not a risk factor in allogeneic hematopoietic stem cell transplantation and does not affect transplant outcomes.

AB - BACKGROUND: A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation and should be a criterion for donor selection. STUDY DESIGN AND METHODS: To further evaluate this issue, 258 consecutive patients who underwent myeloablative or submyeloablative allogeneic hematopoietic stem cell transplantation at our institution were analyzed to determine the association between the Rh mismatch pattern and 5-year actuarial survival. Secondary endpoints analyzed were the association of donor-recipient Rh mismatch and event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), and incidence of chronic GVHD. RESULTS: In our analysis, there were no significant associations between donor-recipient Rh mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute GVHD, or incidence of chronic GVHD. On multivariate Cox proportional hazard analyses, the donor-recipient Rh mismatch pattern was not independently predictive of overall survival. CONCLUSION: Donor-recipient Rh mismatch is not a risk factor in allogeneic hematopoietic stem cell transplantation and does not affect transplant outcomes.

UR - http://www.scopus.com/inward/record.url?scp=37549042053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549042053&partnerID=8YFLogxK

U2 - 10.1111/j.1537-2995.2007.01501.x

DO - 10.1111/j.1537-2995.2007.01501.x

M3 - Article

VL - 48

SP - 163

EP - 168

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 1

ER -