Lack of correlation of symptoms with specialist-assessed long-term asthma severity

Molly Osborne, William M. Vollmer, Katlmjn L. Pedula, John Wilkins, A. Sonia Bitist, Mark O'Hollaren

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Study objectives: To validate three indicators of asthma severity as defined in the National Asthma Education Program (NAEP) guidelines (ie, frequency of symptoms, degree of airflow obstruction, and frequency of use of oral glucocorticoids), alone and in combination, against severity as assessed by pulmonary specialists provided with 24-month medical chart data. Design: Cross-sectional comparison of questionnaire and clinical-based markers of asthma severity with physician-assessed severity based on chart review. The pulmonologists did not have access to the results of the baseline evaluations when making their severity assessments. Setting and participants: Study participants were 193 asthmatic members (age range, 6 to 55 years) of a large health maintenance organization who underwent a baseline evaluation as part of a separate longitudinal study. This evaluation consisted of spirometry, skin prick testing, and a survey that included questions on symptoms and medication use. The participants in the ancillary study were selected, based on their baseline evaluation, to reflect a broad range of asthma severity. Results: Based on the chart review, 86 of the study subjects (45%) had mild disease, 90 (45%) had moderate disease, and 17 (9%) had severe disease. This physician-assessed severity correlated highly (p ≤ 0.013) with NAEP-based indices of severity based on oral glucocorticoid use (never, infrequently for attacks, frequently for attacks, and daily use) and on spirometry (FEV1 > 80% predicted, 60 to 80% predicted, and

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalChest
Volume115
Issue number1
DOIs
StatePublished - 1999

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Asthma
Spirometry
Glucocorticoids
Physicians
Education
Health Maintenance Organizations
Longitudinal Studies
Biomarkers
Guidelines
Lung
Skin
Surveys and Questionnaires

Keywords

  • Asthma
  • Asthma severity
  • Asthma symptoms
  • Chart review

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lack of correlation of symptoms with specialist-assessed long-term asthma severity. / Osborne, Molly; Vollmer, William M.; Pedula, Katlmjn L.; Wilkins, John; Sonia Bitist, A.; O'Hollaren, Mark.

In: Chest, Vol. 115, No. 1, 1999, p. 85-91.

Research output: Contribution to journalArticle

Osborne, Molly ; Vollmer, William M. ; Pedula, Katlmjn L. ; Wilkins, John ; Sonia Bitist, A. ; O'Hollaren, Mark. / Lack of correlation of symptoms with specialist-assessed long-term asthma severity. In: Chest. 1999 ; Vol. 115, No. 1. pp. 85-91.
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