Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

M. M. Nothen, J. Erdmann, J. Korner, M. Lanczik, J. Fritze, R. Fimmers, D. K. Grandy, B. O'Dowd, P. Propping

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    Abstract

    Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

    Original languageEnglish (US)
    Pages (from-to)199-201
    Number of pages3
    JournalAmerican Journal of Psychiatry
    Volume149
    Issue number2
    DOIs
    StatePublished - Jan 1 1992

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    ASJC Scopus subject areas

    • Psychiatry and Mental health

    Cite this

    Nothen, M. M., Erdmann, J., Korner, J., Lanczik, M., Fritze, J., Fimmers, R., Grandy, D. K., O'Dowd, B., & Propping, P. (1992). Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. American Journal of Psychiatry, 149(2), 199-201. https://doi.org/10.1176/ajp.149.2.199