Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

Markus M. Nöthen, Jeanette Erdmann, Judith Körner, Mario Lanczik, Jürgen Fritze, Rolf Fimmers, David Grandy, Brian O'Dowd, Peter Propping

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalAmerican Journal of Psychiatry
Volume149
Issue number2
StatePublished - 1992
Externally publishedYes

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Dopamine D1 Receptors
Dopamine D2 Receptors
Mood Disorders
Bipolar Disorder
Restriction Fragment Length Polymorphisms
Genes
Healthy Volunteers
Alleles
Phenotype

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Nöthen, M. M., Erdmann, J., Körner, J., Lanczik, M., Fritze, J., Fimmers, R., ... Propping, P. (1992). Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. American Journal of Psychiatry, 149(2), 199-201.

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. / Nöthen, Markus M.; Erdmann, Jeanette; Körner, Judith; Lanczik, Mario; Fritze, Jürgen; Fimmers, Rolf; Grandy, David; O'Dowd, Brian; Propping, Peter.

In: American Journal of Psychiatry, Vol. 149, No. 2, 1992, p. 199-201.

Research output: Contribution to journalArticle

Nöthen, MM, Erdmann, J, Körner, J, Lanczik, M, Fritze, J, Fimmers, R, Grandy, D, O'Dowd, B & Propping, P 1992, 'Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder', American Journal of Psychiatry, vol. 149, no. 2, pp. 199-201.
Nöthen MM, Erdmann J, Körner J, Lanczik M, Fritze J, Fimmers R et al. Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. American Journal of Psychiatry. 1992;149(2):199-201.
Nöthen, Markus M. ; Erdmann, Jeanette ; Körner, Judith ; Lanczik, Mario ; Fritze, Jürgen ; Fimmers, Rolf ; Grandy, David ; O'Dowd, Brian ; Propping, Peter. / Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. In: American Journal of Psychiatry. 1992 ; Vol. 149, No. 2. pp. 199-201.
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