@inproceedings{f888f3077d1648498eeec9bc91931d52,
title = "Label-free in vivo optical micro-angiography imaging of cerebral capillary blood flow within meninges and cortex in mice with the skull left intact",
abstract = "Abnormal microcirculation within meninges is common in many neurological diseases. There is a need for an imaging method that is capable of visualizing functional meningeal microcirculations alone, preferably decoupled from the cortical blood flow. Optical microangiography (OMAG) is a recently developed label-free imaging method capable of producing 3D images of dynamic blood perfusion within micro-circulatory tissue beds at an imaging depth up to ~2 mm, with an unprecedented imaging sensitivity to the blood flow at ~4 μm/s. In this study, we demonstrate the utility of ultra-high sensitive OMAG in imaging the detailed blood flow distributions, at a capillary level resolution, within meninges and cortex in mice with the cranium left intact. The results indicate that OMAG can be a valuable tool for the study of meningeal circulations.",
keywords = "Optical microangiography, blood flow, meningeal blood vessel network, microcirculation",
author = "Yali Jia and Wang, {Ruikang K.}",
year = "2011",
doi = "10.1117/12.874110",
language = "English (US)",
isbn = "9780819484260",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV",
note = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV ; Conference date: 24-01-2011 Through 26-01-2011",
}