Label-free 3D optical microangiography imaging of functional vasa nervorum and peripheral microvascular tree in the hind limb of diabetic mice

Jia Yali, Thomas K. Baumann, Ruikang K. Wang

Research output: Contribution to journalArticle

Abstract

Diabetic neuropathy (DN) is, at least in part, associated with the functional attenuation of vasa nervorum, the microvascular structure of peripheral nerves. Microvascular imaging options for vasa nervorum still remain limited. In this work, optical microangiography (OMAG), a volumetric, label-free imaging technique, is utilized for characterizing, with high resolution, blood perfusion of peripheral nerve in diabetic mice. We demonstrate that OMAG is able to visualize the structure of microvasculature and to quantify the changes of dynamic blood flow and vessel diameters during administration of vessel stimulant in both diabetic and normal mice. The results indicate the potential of OMAG to assess the blood supply of nerve involved in the pathology and treatment of DN.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalJournal of Innovative Optical Health Sciences
Volume3
Issue number4
DOIs
StatePublished - Oct 2010

Fingerprint

Vasa Nervorum
Diabetic Neuropathies
Optical Imaging
nerves
limbs
Peripheral Nerves
mice
Labels
Blood
Extremities
Imaging techniques
blood
Microvessels
stimulants
Blood Vessels
Perfusion
blood vessels
pathology
Pathology
blood flow

Keywords

  • diabetes
  • microcirculation
  • optical microangiography
  • peripheral nerve
  • Vasa nervorum

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Medicine (miscellaneous)

Cite this

Label-free 3D optical microangiography imaging of functional vasa nervorum and peripheral microvascular tree in the hind limb of diabetic mice. / Yali, Jia; Baumann, Thomas K.; Wang, Ruikang K.

In: Journal of Innovative Optical Health Sciences, Vol. 3, No. 4, 10.2010, p. 307-313.

Research output: Contribution to journalArticle

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