L-dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys

John Hammerstad, William Woodward, Perry Gliessman, Brian Boucher, John Nutt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The pharmacokinetics of levodopa (L-dopa) in plasma and in cisternal and lumbar cerebrospinal fluid (CSF) were studied in Rhesus monkeys that were given 2- to 3-hour intravenous infusions of L-dopa. Steady-state L-dopa concentrations in cisternal CSF correlated well with plasma levels, and yielded a CSF: plasma ratio of 0.17. The disappearance of L-dopa from plasma and cisternal CSF compartments fits an open, two-compartment pharmacokinetic model. Although slower, the distribution and elimination half-lives for L-dopa from cisternal CSF (8.9 and 49.2 minutes, respectively) were of a similar magnitude to those from plasma (4.9 and 33.2 minutes, respectively). If cisternal CSF reflects brain extracellular fluid, then plasma pharmacokinetics of L-dopa are a reasonable approximation of those in the brain. In contrast to cisternal CSF, the disappearance of L-dopa from lumbar CSF fits an open, one-compartment model with an elimination half-life of 100 minutes. This indicates that the lumbar CSF compartment is unsuitable for investigation of the pharmacokinetics of L-dopa in the brain.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalAnnals of Neurology
Volume27
Issue number5
StatePublished - May 1990

Fingerprint

Levodopa
Haplorhini
Cerebrospinal Fluid
Pharmacokinetics
Brain
Extracellular Fluid
Macaca mulatta
Intravenous Infusions
Half-Life

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

L-dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys. / Hammerstad, John; Woodward, William; Gliessman, Perry; Boucher, Brian; Nutt, John.

In: Annals of Neurology, Vol. 27, No. 5, 05.1990, p. 495-499.

Research output: Contribution to journalArticle

@article{4f9b7cff6830470fa5c044056a4a7600,
title = "L-dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys",
abstract = "The pharmacokinetics of levodopa (L-dopa) in plasma and in cisternal and lumbar cerebrospinal fluid (CSF) were studied in Rhesus monkeys that were given 2- to 3-hour intravenous infusions of L-dopa. Steady-state L-dopa concentrations in cisternal CSF correlated well with plasma levels, and yielded a CSF: plasma ratio of 0.17. The disappearance of L-dopa from plasma and cisternal CSF compartments fits an open, two-compartment pharmacokinetic model. Although slower, the distribution and elimination half-lives for L-dopa from cisternal CSF (8.9 and 49.2 minutes, respectively) were of a similar magnitude to those from plasma (4.9 and 33.2 minutes, respectively). If cisternal CSF reflects brain extracellular fluid, then plasma pharmacokinetics of L-dopa are a reasonable approximation of those in the brain. In contrast to cisternal CSF, the disappearance of L-dopa from lumbar CSF fits an open, one-compartment model with an elimination half-life of 100 minutes. This indicates that the lumbar CSF compartment is unsuitable for investigation of the pharmacokinetics of L-dopa in the brain.",
author = "John Hammerstad and William Woodward and Perry Gliessman and Brian Boucher and John Nutt",
year = "1990",
month = "5",
language = "English (US)",
volume = "27",
pages = "495--499",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - L-dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys

AU - Hammerstad, John

AU - Woodward, William

AU - Gliessman, Perry

AU - Boucher, Brian

AU - Nutt, John

PY - 1990/5

Y1 - 1990/5

N2 - The pharmacokinetics of levodopa (L-dopa) in plasma and in cisternal and lumbar cerebrospinal fluid (CSF) were studied in Rhesus monkeys that were given 2- to 3-hour intravenous infusions of L-dopa. Steady-state L-dopa concentrations in cisternal CSF correlated well with plasma levels, and yielded a CSF: plasma ratio of 0.17. The disappearance of L-dopa from plasma and cisternal CSF compartments fits an open, two-compartment pharmacokinetic model. Although slower, the distribution and elimination half-lives for L-dopa from cisternal CSF (8.9 and 49.2 minutes, respectively) were of a similar magnitude to those from plasma (4.9 and 33.2 minutes, respectively). If cisternal CSF reflects brain extracellular fluid, then plasma pharmacokinetics of L-dopa are a reasonable approximation of those in the brain. In contrast to cisternal CSF, the disappearance of L-dopa from lumbar CSF fits an open, one-compartment model with an elimination half-life of 100 minutes. This indicates that the lumbar CSF compartment is unsuitable for investigation of the pharmacokinetics of L-dopa in the brain.

AB - The pharmacokinetics of levodopa (L-dopa) in plasma and in cisternal and lumbar cerebrospinal fluid (CSF) were studied in Rhesus monkeys that were given 2- to 3-hour intravenous infusions of L-dopa. Steady-state L-dopa concentrations in cisternal CSF correlated well with plasma levels, and yielded a CSF: plasma ratio of 0.17. The disappearance of L-dopa from plasma and cisternal CSF compartments fits an open, two-compartment pharmacokinetic model. Although slower, the distribution and elimination half-lives for L-dopa from cisternal CSF (8.9 and 49.2 minutes, respectively) were of a similar magnitude to those from plasma (4.9 and 33.2 minutes, respectively). If cisternal CSF reflects brain extracellular fluid, then plasma pharmacokinetics of L-dopa are a reasonable approximation of those in the brain. In contrast to cisternal CSF, the disappearance of L-dopa from lumbar CSF fits an open, one-compartment model with an elimination half-life of 100 minutes. This indicates that the lumbar CSF compartment is unsuitable for investigation of the pharmacokinetics of L-dopa in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0025321489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025321489&partnerID=8YFLogxK

M3 - Article

C2 - 2360790

AN - SCOPUS:0025321489

VL - 27

SP - 495

EP - 499

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 5

ER -