L-2-oxothiazolidine-4-carboxylate supplementation in murine γ-GT deficiency

Patrice Held, Cary Harding

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

γ-glutamyl transpeptidase (γ-GT) deficiency in GGTenu1 mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in γ-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGTenu1 mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a cysteine prodrug, led to partial restoration of liver GSH content. The growth, physical appearance, and behavior of γ-GT-deficient mice were substantially improved following OTZ supplementation. Tissue GSH deficiency is the proximate cause of the phenotypic abnormalities associated with murine γ-GT deficiency.

Original languageEnglish (US)
Pages (from-to)1482-1487
Number of pages6
JournalFree Radical Biology and Medicine
Volume34
Issue number11
DOIs
StatePublished - Jun 1 2003

Fingerprint

Liver
gamma-Glutamyltransferase
Prodrugs
Restoration
Glutathione
Cysteine
Tissue
Lethargy
Growth
Cataract
Infertility
2-oxothiazolidine-4-carboxylic acid
4-oxothiazolidine

Keywords

  • γ-Glutamyl transpeptidase
  • Cysteine
  • Free radicals
  • Glutathione
  • L-2-oxothiazolidine-4-carboxylate
  • Mouse model

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Cite this

L-2-oxothiazolidine-4-carboxylate supplementation in murine γ-GT deficiency. / Held, Patrice; Harding, Cary.

In: Free Radical Biology and Medicine, Vol. 34, No. 11, 01.06.2003, p. 1482-1487.

Research output: Contribution to journalArticle

@article{b8c8c643aff640d6a54eb043725151d4,
title = "L-2-oxothiazolidine-4-carboxylate supplementation in murine γ-GT deficiency",
abstract = "γ-glutamyl transpeptidase (γ-GT) deficiency in GGTenu1 mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in γ-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGTenu1 mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a cysteine prodrug, led to partial restoration of liver GSH content. The growth, physical appearance, and behavior of γ-GT-deficient mice were substantially improved following OTZ supplementation. Tissue GSH deficiency is the proximate cause of the phenotypic abnormalities associated with murine γ-GT deficiency.",
keywords = "γ-Glutamyl transpeptidase, Cysteine, Free radicals, Glutathione, L-2-oxothiazolidine-4-carboxylate, Mouse model",
author = "Patrice Held and Cary Harding",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S0891-5849(03)00181-3",
language = "English (US)",
volume = "34",
pages = "1482--1487",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - L-2-oxothiazolidine-4-carboxylate supplementation in murine γ-GT deficiency

AU - Held, Patrice

AU - Harding, Cary

PY - 2003/6/1

Y1 - 2003/6/1

N2 - γ-glutamyl transpeptidase (γ-GT) deficiency in GGTenu1 mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in γ-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGTenu1 mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a cysteine prodrug, led to partial restoration of liver GSH content. The growth, physical appearance, and behavior of γ-GT-deficient mice were substantially improved following OTZ supplementation. Tissue GSH deficiency is the proximate cause of the phenotypic abnormalities associated with murine γ-GT deficiency.

AB - γ-glutamyl transpeptidase (γ-GT) deficiency in GGTenu1 mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in γ-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGTenu1 mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a cysteine prodrug, led to partial restoration of liver GSH content. The growth, physical appearance, and behavior of γ-GT-deficient mice were substantially improved following OTZ supplementation. Tissue GSH deficiency is the proximate cause of the phenotypic abnormalities associated with murine γ-GT deficiency.

KW - γ-Glutamyl transpeptidase

KW - Cysteine

KW - Free radicals

KW - Glutathione

KW - L-2-oxothiazolidine-4-carboxylate

KW - Mouse model

UR - http://www.scopus.com/inward/record.url?scp=0038368911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038368911&partnerID=8YFLogxK

U2 - 10.1016/S0891-5849(03)00181-3

DO - 10.1016/S0891-5849(03)00181-3

M3 - Article

VL - 34

SP - 1482

EP - 1487

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 11

ER -