Kisspeptin excitation of GnRH neurons

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Abstract

Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.

Original languageEnglish (US)
Title of host publicationKisspeptin Signaling in Reproductive Biology
PublisherSpringer New York LLC
Pages113-131
Number of pages19
ISBN (Print)9781461461982
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume784
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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