Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K + excretion

Xiao Tong Su, David Ellison, Wen Hui Wang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this mini review is to provide an overview regarding the role of inwardly rectifying potassium channel 4.1 (Kir4.1)/Kir5.1 in regulating renal K+ excretion. Deletion of Kir4.1 in the kidney inhibited thiazide-sensitive NaCl cotransporter (NCC) activity in the distal convoluted tubule (DCT) and slightly suppressed Na-K-2Cl cotransporter (NKCC2) function in the thick ascending limb (TAL). Moreover, increased dietary K+ intake inhibited, whereas decreased dietary K+ intake stimulated, the basolateral potassium channel (a Kir4.1/Kir5.1 heterotetramer) in the DCT. The alteration of basolateral potassium conductance is essential for the effect of dietary K+ intake on NCC because deletion of Kir4.1 in the DCT abolished the effect of dietary K+ intake on NCC. Since potassium intake-mediated regulation of NCC plays a key role in regulating renal K+ excretion and potassium homeostasis, the deletion of Kir4.1 caused severe hypokalemia and metabolic alkalosis under control conditions and even during increased dietary K+ intake. Finally, recent studies have suggested that the angiotensin II type 2 receptor (AT2R) and bradykinin-B2 receptor (BK2R) are involved in mediating the effect of high dietary K+ intake on Kir4.1/Kir5.1 in the DCT.

Original languageEnglish (US)
Pages (from-to)F582-F586
JournalAmerican journal of physiology. Renal physiology
Volume316
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Potassium
Member 1 Solute Carrier Family 12
Angiotensin Type 2 Receptor
Bradykinin B2 Receptors
Inwardly Rectifying Potassium Channel
Alkalosis
Hypokalemia
Potassium Channels
Homeostasis
Extremities
Kidney
Renal Elimination
thiazide receptor

Keywords

  • distal convoluted tubule
  • K excretion
  • NCC
  • NKCC2

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K + excretion . / Su, Xiao Tong; Ellison, David; Wang, Wen Hui.

In: American journal of physiology. Renal physiology, Vol. 316, No. 3, 01.03.2019, p. F582-F586.

Research output: Contribution to journalArticle

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