Key binding interactions for memantine in the NMDA receptor

Walrati Limapichat, Wesley Y. Yu, Emma Branigan, Henry A. Lester, Dennis A. Dougherty

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Memantine (Namenda) is prescribed as a treatment for moderate to severe Alzheimer's Disease. Memantine functions by blocking the NMDA receptor, but the key binding interactions between drug and receptor are not fully elucidated. To determine key binding interactions of memantine, we made side-by-side comparisons of IC50 for memantine and amantadine, a structurally related drug, in the GluN1/GluN2B NMDA receptor. We identified hydrophobic binding pockets for the two methyl groups on memantine formed by the residues A645 and A644 on the third transmembrane helices of GluN1 and GluN2B, respectively. Moreover, we found that while adding two methyl groups to amantadine to produce memantine greatly improves affinity, adding a third methyl group to produce the symmetrical trimethylamantadine diminished affinity. Our results provide a better understanding of chemical-scale interactions between memantine and the NMDA channel, which will potentially benefit the development of new drugs for neurodegenerative diseases involving NMDA receptors.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalACS Chemical Neuroscience
Volume4
Issue number2
DOIs
StatePublished - Feb 20 2013
Externally publishedYes

Keywords

  • Memantine
  • amantadine
  • open-channel blocker
  • unnatural amino acid mutagenesis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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