Ketamine protects hippocampal neurons from anoxia in vitro

S. M. Rothman, J. H. Thurston, R. E. Hauhart, G. D. Clark, J. S. Solomon

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    95 Scopus citations

    Abstract

    Ketamine, a dissociative, general anesthetic, blocks the excitation produced by activating one class of excitatory amino acid receptors, the N-methyl-d-aspartate receptor in the rat. We have found that ketamine can protect hippocampal neurons in culture and slice from anoxia. When added to cultures immediately prior to anoxic exposure, ketamine prevented the neuronal destruction seen after a day of anoxia. Neurons appeared undamaged and had normal resting and action potentials. Adenosine triphosphate levels in ketamine-protected anoxic cultures were approximately two-thirds of normal controls. Ketamine also prevented the irreversible loss of the population spike seen in hippocampal slices after prolonged perfusion with anoxic buffer. These results suggest that ketamine may have therapeutic potential in preventing anoxic damage from stroke in man.

    Original languageEnglish (US)
    Pages (from-to)673-678
    Number of pages6
    JournalNeuroscience
    Volume21
    Issue number3
    DOIs
    StatePublished - Jun 1987

    ASJC Scopus subject areas

    • Neuroscience(all)

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  • Cite this

    Rothman, S. M., Thurston, J. H., Hauhart, R. E., Clark, G. D., & Solomon, J. S. (1987). Ketamine protects hippocampal neurons from anoxia in vitro. Neuroscience, 21(3), 673-678. https://doi.org/10.1016/0306-4522(87)90028-5