TY - GEN
T1 - Kernelized Bayesian transfer learning
AU - Gönen, Mehmet
AU - Margolin, Adam A.
PY - 2014
Y1 - 2014
N2 - Transfer learning considers related but distinct tasks defined on heterogenous domains and tries to transfer knowledge between these tasks to improve generalization performance. It is particularly useful when we do not have sufficient amount of labeled training data in some tasks, which may be very costly, laborious, or even infeasible to obtain. Instead, learning the tasks jointly enables us to effectively increase the amount of labeled training data. In this paper, we formulate a kernelized Bayesian transfer learning framework that is a principled combination of kernel-based dimensionality reduction models with task-specific projection matrices to find a shared subspace and a coupled classification model for all of the tasks in this subspace. Our two main contributions are: (i) two novel probabilistic models for binary and multiclass classification, and (ii) very efficient variational approximation procedures for these models. We illustrate the generalization performance of our algorithms on two different applications. In computer vision experiments, our method outperforms the state-of-the-art algorithms on nine out of 12 benchmark supervised domain adaptation experiments defined on two object recognition data sets. In cancer biology experiments, we use our algorithm to predict mutation status of important cancer genes from gene expression profiles using two distinct cancer populations, namely, patient-derived primary tumor data and in-vitro-derived cancer cell line data. We show that we can increase our generalization performance on primary tumors using cell lines as an auxiliary data source.
AB - Transfer learning considers related but distinct tasks defined on heterogenous domains and tries to transfer knowledge between these tasks to improve generalization performance. It is particularly useful when we do not have sufficient amount of labeled training data in some tasks, which may be very costly, laborious, or even infeasible to obtain. Instead, learning the tasks jointly enables us to effectively increase the amount of labeled training data. In this paper, we formulate a kernelized Bayesian transfer learning framework that is a principled combination of kernel-based dimensionality reduction models with task-specific projection matrices to find a shared subspace and a coupled classification model for all of the tasks in this subspace. Our two main contributions are: (i) two novel probabilistic models for binary and multiclass classification, and (ii) very efficient variational approximation procedures for these models. We illustrate the generalization performance of our algorithms on two different applications. In computer vision experiments, our method outperforms the state-of-the-art algorithms on nine out of 12 benchmark supervised domain adaptation experiments defined on two object recognition data sets. In cancer biology experiments, we use our algorithm to predict mutation status of important cancer genes from gene expression profiles using two distinct cancer populations, namely, patient-derived primary tumor data and in-vitro-derived cancer cell line data. We show that we can increase our generalization performance on primary tumors using cell lines as an auxiliary data source.
UR - http://www.scopus.com/inward/record.url?scp=84908154456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908154456&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84908154456
T3 - Proceedings of the National Conference on Artificial Intelligence
SP - 1831
EP - 1839
BT - Proceedings of the National Conference on Artificial Intelligence
PB - AI Access Foundation
T2 - 28th AAAI Conference on Artificial Intelligence, AAAI 2014, 26th Innovative Applications of Artificial Intelligence Conference, IAAI 2014 and the 5th Symposium on Educational Advances in Artificial Intelligence, EAAI 2014
Y2 - 27 July 2014 through 31 July 2014
ER -