Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets

Jae Il Park, Si Wan Kim, Jon P. Lyons, Hong Ji, Thi T. Nguyen, Kyucheol Cho, Michelle C. Barton, Tom Deroo, Kris Vleminckx, Pierre D. McCrea

Research output: Contribution to journalArticlepeer-review

188 Scopus citations


β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to β-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased β-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of β-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and β-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.

Original languageEnglish (US)
Pages (from-to)843-854
Number of pages12
JournalDevelopmental Cell
Issue number6
StatePublished - Jun 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets'. Together they form a unique fingerprint.

Cite this