Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets

Jae Il Park; Si Wan Kim; Jon P. Lyons; Hong Ji; Thi T. Nguyen; Kyucheol Cho; Michelle C. Barton; Tom Deroo; Kris Vleminckx; Pierre D. McCrea

doi:10.1016/j.devcel.2005.04.010

Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets

Jae Il Park, Si Wan Kim, Jon P. Lyons, Hong Ji, Thi T. Nguyen, Kyucheol Cho, Michelle C. Barton, Tom Deroo, Kris Vleminckx, Pierre D. McCrea

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to β-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased β-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of β-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and β-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.

Original language	English (US)
Pages (from-to)	843-854
Number of pages	12
Journal	Developmental Cell
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2005.04.010
State	Published - Jun 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2005.04.010

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@article{c406d6936701448086df1f52aab9eea3,

title = "Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets",

abstract = "β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to β-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased β-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of β-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and β-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.",

author = "Park, {Jae Il} and Kim, {Si Wan} and Lyons, {Jon P.} and Hong Ji and Nguyen, {Thi T.} and Kyucheol Cho and Barton, {Michelle C.} and Tom Deroo and Kris Vleminckx and McCrea, {Pierre D.}",

note = "Funding Information: We thank Randall T. Moon (U. Washington) for xTCF-3 antiserum, Jiemin Wong (Baylor College of Medicine) for N-CoR antiserum, Warren S.-L. Liao, Lei Li, and Mong-Hong Lee for constructive comments, Sohee Jun and Xiang Fang for technical assistance, and Catherine Papasakelariou and Travis Vaught for helpful reading of the manuscript. This work was supported by NIH RO1 (GM52112) and an Institutional Research Grant. DNA sequencing and other core facilities were supported by a UT MDACC NCI Core Grant CA-16672. T.D. and K.V. are supported by a grant from the Interuniversitaire Attractiepolen, and K.V. is a postdoctoral fellow with the FWO. ",

year = "2005",

month = jun,

doi = "10.1016/j.devcel.2005.04.010",

language = "English (US)",

volume = "8",

pages = "843--854",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "6",

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TY - JOUR

T1 - Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets

AU - Park, Jae Il

AU - Kim, Si Wan

AU - Lyons, Jon P.

AU - Ji, Hong

AU - Nguyen, Thi T.

AU - Cho, Kyucheol

AU - Barton, Michelle C.

AU - Deroo, Tom

AU - Vleminckx, Kris

AU - McCrea, Pierre D.

N1 - Funding Information: We thank Randall T. Moon (U. Washington) for xTCF-3 antiserum, Jiemin Wong (Baylor College of Medicine) for N-CoR antiserum, Warren S.-L. Liao, Lei Li, and Mong-Hong Lee for constructive comments, Sohee Jun and Xiang Fang for technical assistance, and Catherine Papasakelariou and Travis Vaught for helpful reading of the manuscript. This work was supported by NIH RO1 (GM52112) and an Institutional Research Grant. DNA sequencing and other core facilities were supported by a UT MDACC NCI Core Grant CA-16672. T.D. and K.V. are supported by a grant from the Interuniversitaire Attractiepolen, and K.V. is a postdoctoral fellow with the FWO.

PY - 2005/6

Y1 - 2005/6

N2 - β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to β-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased β-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of β-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and β-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.

AB - β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to β-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kaiso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased β-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kaiso suppression of β-catenin-induced axis duplication and by TCF-3 rescue of Kaiso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and β-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.

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DO - 10.1016/j.devcel.2005.04.010

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AN - SCOPUS:19944425163

SN - 1534-5807

VL - 8

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EP - 854

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Kaiso/p120-Catenin and TCF/β-Catenin complexes coordinately regulate canonical Wnt gene targets

Abstract

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