Kainic acid neurotoxicity in granuloprival cerebellar cultures

Fredrick J. Seil, William Woodward

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10-3 Md-glutamic acid or 10-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBrain Research
Volume197
Issue number1
DOIs
StatePublished - Sep 15 1980

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Kainic Acid
Glutamic Acid
Neurons
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Keywords

  • cerebellar cultures
  • glutamatergic fibers
  • kainic acid
  • neurotoxicity

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kainic acid neurotoxicity in granuloprival cerebellar cultures. / Seil, Fredrick J.; Woodward, William.

In: Brain Research, Vol. 197, No. 1, 15.09.1980, p. 285-289.

Research output: Contribution to journalArticle

Seil, Fredrick J. ; Woodward, William. / Kainic acid neurotoxicity in granuloprival cerebellar cultures. In: Brain Research. 1980 ; Vol. 197, No. 1. pp. 285-289.
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