Kainic acid neurotoxicity in granuloprival cerebellar cultures

Fredrick J. Seil, William R. Woodward

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10-3 Md-glutamic acid or 10-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBrain research
Volume197
Issue number1
DOIs
StatePublished - Sep 15 1980

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Keywords

  • cerebellar cultures
  • glutamatergic fibers
  • kainic acid
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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