Kainic acid neurotoxicity in granuloprival cerebellar cultures

Fredrick J. Seil; William R. Woodward

doi:10.1016/0006-8993(80)90461-8

Kainic acid neurotoxicity in granuloprival cerebellar cultures

Fredrick J. Seil, William R. Woodward

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10^-3 Md-glutamic acid or 10^-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.

Original language	English (US)
Pages (from-to)	285-289
Number of pages	5
Journal	Brain research
Volume	197
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)90461-8
State	Published - Sep 15 1980

Keywords

cerebellar cultures
glutamatergic fibers
kainic acid
neurotoxicity

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(80)90461-8

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title = "Kainic acid neurotoxicity in granuloprival cerebellar cultures",

abstract = "Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10-3 Md-glutamic acid or 10-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.",

keywords = "cerebellar cultures, glutamatergic fibers, kainic acid, neurotoxicity",

author = "Seil, {Fredrick J.} and Woodward, {William R.}",

note = "Funding Information: Supported by the Veterans Admimstratmn (F.J.S.) and Pubhc Health Servme Grant EY02456 (W.R.W.). The technicala ssistanceo f Benson Fong, Joseph Pxerce and Jean Qulgley is gratefullya cknowledged.",

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AU - Seil, Fredrick J.

AU - Woodward, William R.

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Y1 - 1980/9/15

N2 - Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10-3 Md-glutamic acid or 10-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.

AB - Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10-3 Md-glutamic acid or 10-4 M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.

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KW - glutamatergic fibers

KW - kainic acid

KW - neurotoxicity

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Kainic acid neurotoxicity in granuloprival cerebellar cultures

Abstract

Keywords

ASJC Scopus subject areas

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